Stimulants and psychomimetic drugs Flashcards
Amphetamine
amphetamine
-Reverse NAT and DAT
-taken by VMAT to displace NT
-inhibit MAO
—-
stimulant
—-
-locomotor stim
-anorexia
-anxiety
dextroamphetamine
amphetamine
-Reverse NAT and DAT
-taken by VMAT to displace NT
-inhibit MAO
—-
stimulant for ADHD
—-
-locomotor stim
-anorexia
-anxiety
Mephedrone
cathinone derivative (Khat)
-elevates extracellular DA and 5-HT, maybe by reuptake
—
stimulant
—
-locomotor stim
-anorexia
-anxiety
Methylphenidate
amphetamine (ritalin)
-inhibit NET/DAT but not reverse
-inhibits SERT but only a little
—
stimulant for ADHD
narcolepsy
—
-locomotor stim
-anorexia
-anxiety
Modafinil
stimulant
-inhibits DAT
—
narcolepsy
improves memory and executive function
—
-locomotor stim
-anorexia
-anxiety
Cocaine
from coco shrub
-Inhibits NET,DAT, SERT
-talkativeness, motor activity
—-
stimulant
can be a local anaesthetic
—
-strong phycological dependance
-less hallucinations/ paranoia
-convulsions
-heart issues
Caffeine
Methylxanthine
-A2 adenosine receptor antagonist
-PDE inhibitor
—-
mild CNS stim
diuretic
broncho dilator
—
LSD
psychomimetic
-5-HT2a agonist
—-
hallucinogen
-experience of trip stays with them
-usually aware it is drugs
Psilocybin
psychomimetic
-5-HT2a agonist
–
hallucinogen
-experience of trip stays with them
-usually aware it is drugs
MDMA
psychomimetic
-inhibits NET,DAT, SERT
—
stimulant and hallucinogen
—
-serotonin syndrome
-heart failure
Mescaline
psychomimetic
-unknown mechanism but effects 5-HT?
—
hallucinogen
Ketamine (Hallucinogen)
/
Blocks NMDA channels (unknown how this effects perception)
—
hallucinogen
dissociative anaesthetic
—
abdominal pain
liver damage
cognitive impairment
PCP
/
Blocks NMDA channels (unknown how this effects perception)
—
hallucinogen
dissociative anaesthetic
—
abdominal pain
liver damage
cognitive impairment
-can cause psychotic breaks
