anxiolytic and hypnotic drugs

Question 1

Lorazepam

Answer 1

Benzodiazepine
-allostericly effect GABAa
enhance opening
—
-anxiolytic (2)
-sedative (1)
-amnestc (5)
—-
-imparied coordination
-don’t mix with EtOH

Question 2

Flumazenil

Answer 2

Benzo antagonist
to reverse effect of benzodiazepines overdose

Question 3

Buspirone

Answer 3

5-HT1a partial agonist
-activate and desensitize presynaptic inhibitory receptors increasing release
—
-anxiolytic (takes weeks)
-not effective for phobias
—
-dizzines
-nausea
-headache (increase serotonin)

Question 4

Propranolol (anxiety)

Answer 4

beta blocker
treats the somatic effects of anxiety

Question 5

Antidepressants (anxiety)

Answer 5

usually SSRIs have similar effect to busprione and take as long to act (weeks)
-also helps with combo depression + anxiety

Question 6

Zolpidem

Answer 6

Benzo like
-selectively bind alpha 1
—
-sedating/hypnotic

Question 7

Zopiclone

Answer 7

Benzo like
-selectively bind alpha 1
—
-sedating/hypnotic

Question 8

Zaleplon

Answer 8

Benzo like
-selectively bind alpha 1 GABAsubunit
—
-sedating/hypnotic

Question 9

Diphenhydramine

Answer 9

H1 inverse agonist in CNS
-with anticholinergic for sleepy effects
—
sedation/hypnotic

Question 10

Melatonin

Answer 10

/
-MT1/MT2 agonist in SCN
—-
-sedation

Question 11

Ramelteon

Answer 11

Melatonin analog
MT1/MT2 agonist
—
-sedation