anti arrhythmic facts

Question 1

Pace maker AP working

Answer 1

1.spontaneous depolarization from funny Na+ channels
2.Last push to threshold from T-type Ca+ channels
3.Rapid depol, from L-type Ca+ channels
4.K+ channels rapid repolarization

Question 2

Contractile cell AP

Answer 2

Phase 0:Na+ channels with rapid depol.
1:Na+ channel inactivate and small repol
2.K+ small movement out, L-type Ca+ channels open
3.delayed K+ rectifier channels open for rapid repol. L-type close
4.K+ channels are open and Na/Ca channels are closed. resting

Question 3

ERP

Answer 3

effective refractory period
Time between depol and earliest time a early stim could trigger new AP

Question 4

Torsades de pointes

Answer 4

Twisting of points when a early stim depolarizes a cell leading to a fib

Question 5

Class 1 anti-arrhythmics

Answer 5

Na+ channel blockers
slow conduction velocity
bind readily to open or inactivated state

Question 6

Class 2 anti-arrhythmics

Answer 6

Control rate
beta blockers
decrease CO and HR

Question 7

Class 3 anti-arrhythmics

Answer 7

K+ channel blockers
lengthen repolariztion

Question 8

Class 4

Answer 8

Ca+ channel blockers