Lipid lowering drugs

Question 1

Atorvastatin

Answer 1

Statin
-inhibit HMG-CoA and prevent cholesterol synthesis
—
-dyslipidemia
long half life highly protein bound
—
myopathy
increases glucose

Question 2

rosuvastatin

Answer 2

Statin
-inhibit HMG-CoA and prevent cholesterol synthesis
—
-dyslipidemia
long half life highly protein bound
—
myopathy
increases glucose

Question 3

Clofibrate

Answer 3

Fibrate
-Binds PARR alpha
-action unknown but does lower VLDL
—
dyslipidemia
highly protein bound
urine excreted
—
5% get GI effects

Question 4

Gemfibrozil

Answer 4

Fibrate
-Binds PARR alpha
-action unknown but does lower VLDL
—
dyslipidemia
highly protein bound
urine excreted
—
5% get GI effects

Question 5

Ezetimibe

Answer 5

-inhibits NPC1L1 for cholesterol uptake
-stimulates LDL receptor LDL clearance
—
dyslipidemia
—
-gall stones

Question 6

Cholestryarmine

Answer 6

bile acid seqest
-force bile acid synthesis using cholesterol
—
dyslipidemia
—-
very safe but can interfere with other drug absorption

Question 7

Colestipol

Answer 7

bile acid seqest
-force bile acid synthesis using cholesterol
—
dyslipidemia
—-
very safe but can interfere with other drug absorption

Question 8

Niacin

Answer 8

/
-reduces synthesis of LDL/VLDL and increases HDL-C
—
dyslipidemia
best one for increasing HDL-C
—
Flushing
gout

Question 9

alirocumab

Answer 9

PCSK9 inhibitor
-stimulate LDL receptor recycling
-lower LDL)
—
dyslipidemia
used alongside statins
—
expensive

Question 10

Evolovcumab

Answer 10

PCSK9 inhibitor
-stimulate LDL receptor recycling
-lower LDL)
—
dyslipidemia
used alongside statins
—
expensive