Analgesics drugs

Question 1

Morphine

Answer 1

opioid analgesic
-mu opioid receptor agonist
-mu opioid receptors open K+ channels to hyper polarize
-inhibits Ca+ channels
—
analgesic
—-
-respiratory depression
-constipation
-pupil constriction
-histamine release

Question 2

ASA

Answer 2

NSAID
-inhibits COX1/2 and prevents prostaglandin PGE2 PGF2alpha
—-
-pain (analgesic)
-anti-inflammatory/pyretic
—
-stomach ulcers

Question 3

Acetominophen

Answer 3

NSAID
-maybe inhibits COX
—
-pain (analgesic)
-anti pyretic (not anti inflammatory)
—
-no GI side effects

Question 4

Tricyclic antidepressants (pain)

Answer 4

Amitripyline, nortyrptaline, desipramine
-inhibit NE reuptake CNS
-activate NE pain suppression
—
-neuropathic pain
—

Question 5

Antiepiletpic drugs

Answer 5

gabapentin,carbamazepine
-reduce VG Ca+ channels
-Block VG Na+ channels
-maybe prevent transmission of pain signals
—
Neuropathic pain
—