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Pharm 203 > Drugs midterm 1 > Flashcards

Drugs midterm 1 Flashcards

1
Q

Acetylcholine

A

AcHR agonist
-decrease HR,BP (via NO)
-visceral SM contraction
-increase glandular secretion

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2
Q

Pilocarpine

A

mAcHR agonist
-decrease HR,BP (via NO)
-visceral SM contraction
-increase glandular secretion
———
-Glaucoma (decrease ocular pressure)
-Sjogrens syndrome

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3
Q

Cevimeline

A

mAcHR agonist
-decrease HR,BP (via NO)
-visceral SM contraction
-increase glandular secretion
———
-Sjogrens syndrome (increase secretion)

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4
Q

Atropine

A

mAcHR antagonist
-increase HR,BP,
-decrease glandular secretion
-relax lungs, bladder, GI
————
-Bradycardia
-organophosphate poising

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5
Q

Hyoscine

A

mAcHR antagonist
-increase HR,BP,
-decrease glandular secretion
-relax lungs, bladder, GI
————
-Relax GI for endoscopy
-anti emetic effect

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6
Q

Trapicamide

A

mAcHR antagonist
-increase HR,BP,
-decrease glandular secretion
-relax lungs, bladder, GI
————
-dilate pupils (SM relaxation)

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7
Q

Ipratropium

A

mAcHR antagonist
-increase HR,BP,
-decrease glandular secretion
-relax lungs, bladder, GI
————
-asthma/COPD, relax lung SM

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8
Q

Benzotropine

A

mAcHR antagonist
-increase HR,BP,
-decrease glandular secretion
-relax lungs, bladder, GI
————
-Parkinsons (decreases unwanted movement)

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9
Q

Pancuronium

A

nAcHR antagonist
-non-depolarizing muscle block paralysis (motor endplate)
———-
N/A
———-
-Tachycardia from mAcHr block in heart
-Histamine release

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10
Q

Vecuronium

A

nAcHR antagonist
-non-depolarizing muscle block paralysis (motor endplate)
———-
N/A
———-
-Histamine release

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11
Q

Mivacurium

A

nAcHR antagonist
-non-depolarizing muscle block paralysis (motor endplate)
———-
N/A
———-
-Histamine release

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12
Q

Suxamethonium

A

nAcHR agonist
-depolarizing muscle block (long binding action keeps depolarized)
——–
N/A
——–
-bradycardia/ dysrhythmia (M2 agonist)
-increased ocular pressure (M3 agonist)

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13
Q

Botulinum toxin

A

wrinkle treatment
——-

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14
Q

Neostigmine

A

Acetylcholinesterase enzyme inhibitor
-increase muscle tension (paralysis at high dose)
-CNS excitation then depression (depolarizing block)
———-
-myasthenia graves
———–
-unconsciousness (CNS depression)
-resp. failure

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15
Q

Physostigmine

A

Acetylcholinesterase enzyme inhibitor
-increase muscle tension (paralysis at high dose)
-CNS excitation then depression (depolarizing block)
———-
-myasthenia graves
———–
-unconsciousness (CNS depression)
-resp. failure

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16
Q

Adrenaline

A

Adrenergic Agonist
-increase BR,HR
-Constrict SM
———–
-hypotension
-anaphylactic shock
-cardiac arrest
————
-hypertension
-tachycardia
-reflex bradycardia

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17
Q

Noradrenaline

A

Adrenergic Agonist
-increase BR,HR
-Constrict SM
———–
-hypotension
————
-hypertension
-tachycardia
-reflex bradycardia

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18
Q

Phenylephrine

A

Alpha 1 adrenergic agonist
-Constrict SM
———-
-nasal congestion (via decreased blood flow
———-
-reflex bradycardia (response to high BP)
-hypertension

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19
Q

Salbutamol

A

Beta 2 adrenergic agonist
-Relax SM
-Increase HR/BP
——–
-asthma
-delayed labour
———-
-tachycardia
-tremor
-peripheral vasodilation

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20
Q

Salmuterol

A

Beta 2 adrenergic agonist
-Relax SM
-Increase HR/BP
——–
-asthma
———-
-tachycardia
-tremor
-peripheral vasodilation

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21
Q

Mirabegron

A

Beta 3 Adrenergic agonist
-Relax bladder
——-
overactive bladder
———
tachycardia

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22
Q

Phenoxybenzamine

A

Alpha adrenergic antagonist
-relax SM
——–
pheochromocytoma
———
-hypotension
-reflex tachycardia
-nasal congestion

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23
Q

Prazosin

A

alpha 1 adrenergic antagonist
-relax SM to lower BP
——–
-hypertension
———
-nasal congestion
-hypotension
-reflex tachycardia

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24
Q

Doxazosin

A

alpha 1 adrenergic antagonist
-relax SM to lower BP
——–
-hypertension
———
-nasal congestion
-hypotension
-reflex tachycardia

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25
Q

Propanolol

A

Beta adrenergic antagonist
-constrict SM
-lower HR
——–
-hypertension
-angina
-tremor
-glaucoma
———-
-Bradycardia
-hypotension
-lung SM constriction

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26
Q

alprenolol

A

Beta adrenergic partial agonist
-constrict SM
-lower HR
——–
-hypertension
-angina
-tremor
-glaucoma
———-
-Bradycardia
-hypotension
-lung SM constriction

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27
Q

Metoprolol

A

Beta 1 adrenergic antagonist
-decrease HR
-less broncoconstriction b/c of selectivity
——–
-hypertension
-angina
-heart failure
——-
-cardiac failure
-cold limbs
-fatigue

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28
Q

atenolol

A

Beta 1 adrenergic antagonist
-decrease HR
-less broncoconstriction b/c of selectivity
——–
-hypertension
-angina
-heart failure
——-
-cardiac failure
-cold limbs
-fatigue

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29
Q

Nebivolol

A

Beta 1 adrenergic antagonist
-Lower heart rate
-Dilate BV with NO release
———
-hypertension
———-
-Headache from dilation (NO)

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30
Q

Labetalol

A

-hypertension during pregnancy
——-
-hypotension
-bronco constriction

31
Q

Carvedilol

A

-Heart failure
——–
-hypotension
-reflex tachycardia
-nasal congestion

32
Q

Alpha-methyl-tyrosine

A

tyrosine hydroxylate inhibitor
-prevents NA and adrenaline synthesis
——–
-phaeochromocytoma
———
-hypotension
-sedation

33
Q

Methyldopa

A

Prodrug for methylnoradreanline

34
Q

Methylnoradreanline

A

adrenergic partial agonist
-metabolite of methyldopa
-not degraded by MAO
-will displace NA
——–
-hypertension during pregnancy
——–
-hypotension
-sedation
-diarrhoea

35
Q

L-DOPS

A

-neurogenic orthostatic hypotension
——
-hypertension : excitement : convulsions

36
Q

amphetamine

A

NA modulator (agonist)
-enters and displaces NA from vesicles
-inhibits NA reuptake
———
-ADHA
———
-hypertension
-dependence

37
Q

ephedrine

A

Beta adrenergic agonist
-Also stimulates NA release
———
-decongestant
-CNS stim
——-
-hypertension
-dependence

38
Q

imipramine

A

Inhibits NET (transporter)
-also anticholinergic
———
-depression
——-
-tachycardia
-drymouth (cholinergic M3)
-constipation

39
Q

cocaine

A

-CNS stim
-local anesthetic
——-
-hypertension
-convulsions

40
Q

Cimetidine

A

H2 receptor antagonist
-reduces gastric acid secretion
———
stomach acid issues
———

41
Q

Diphenhydramine

A

H1 receptor inverse agonist
-frist gen antihistamine
-reduces immune response
———
-allergies
-sleep
———-
-has anti, choleric, adrenergic and serotinergic effect
-from that major sedation

42
Q

Hydroxyzine

A

H1 receptor inverse agonist
-frist gen antihistamine
-reduces immune response
———
-allergies
-sleep
———-
-has anti, choleric, adrenergic and serotinergic effect
-from that major sedation

43
Q

Certirzine

A

H1 receptor inverse agonist
-2/3rd gen antihistamine
-prevent immune response
-less sedation due to selectivity and glycoprotein substrate
——
-allergies
——

44
Q

Loratadine

A

H1 receptor inverse agonist
-2/3rd gen antihistamine
-prevent immune response
-less sedation due to selectivity and glycoprotein substrate
——
-allergies
——

45
Q

Fexofenadine

A

H1 receptor inverse agonist
-2/3rd gen antihistamine
-prevent immune response
-less sedation due to selectivity and glycoprotein substrate
——
-allergies
——

46
Q

Levocetrizine

A

H1 receptor inverse agonist
-2/3rd gen antihistamine
-prevent immune response
-less sedation due to selectivity and glycoprotein substrate
——
-allergies
——

47
Q

desloratadine

A

H1 receptor inverse agonist
-2/3rd gen antihistamine
-prevent immune response
-less sedation due to selectivity and glycoprotein substrate
——
-allergies
——

48
Q

Sumatriptan

A

5-HT B1 agonist
-constrict cerebral arteries and inhibits trigeminal nerves
——-
-aborts migraines
——–
-coronary vasoconstriction
-dysrhythmia

49
Q

Other triptans

A

5-HT B1 agonist (all less potent than sumatriptan)
-constrict cerebral arteries and inhibits trigeminal nerves
——-
-aborts migraines
——–
-coronary vasoconstriction
-dysrhythmia

50
Q

Pizotifen

A

5-HT 2 antagonist
-inhibits cerebral artery constriction
——–
-prevents migrane from starting
———
-weight gain
-sedation
-antimuscarinic effects

51
Q

Adalimumab

A

Interleukins
-Inhibits interlukin TNF alpha which reduces inflammation
——-
-rheumatoid arthritis
-chronhns disease

52
Q

Alprostadil

A

PGE2 analog
-vasodilation
-pyrogenic
-lung and GI SM effects
——
-Peripheral vasodilation

53
Q

Misoprostol

A

PGE 2 analog
-vasodilation
-GI acid inhibition
-GI muscus stimulation
-cervix ripening
-uturine contractions
———–
-ulcer prevention from NSAIDS
-labour induction

54
Q

Gemeprost

A

PGE 2 analog
-vasodilation
-cervix ripening
-uturine contractions
——-
abortion/ induce labour

55
Q

Carboprost

A

PGF2 alpha analog
-uterine contraction
——
-Prevent bleeding after birth

56
Q

Lantanoprost

A

PGF2 Alpha analog
-leaks fluid out of the eye
——-
-glaucoma

57
Q

epoprostenol

A

PGI2 analog
-vasodilation
-anti clotting
——-
-pulmonary hypertension

58
Q

Zafirlukast

A

CysLT antagonist
-lung SM dilation (via block of leukotriene receptor)
——-
-asthma

59
Q

Montelukast

A

CysLT antagonist
-lung SM dilation (via block of leukotriene receptor)
——-
-asthma

60
Q

Nabiximols

A

CB1/2 agonist
-analgesia
—–
-for pain

61
Q

Nabilone

A

CB1/2 agonist
-anti-emetic
—-
-for people with cancer

62
Q

Theophylline

A

Adenosine 1 receptor antagonist
-bronchodilation
——-
-asthma

63
Q

ADP

A

P2Y agonist
-stimulates clotting

64
Q

ATP

A

P2X agonist
-vasodilation (blocks K+ channels)
-insulin secretion
-pain transmission
-inflammation
————
-released from damaged cells to signal issue

65
Q

Glucocorticoids

A

iNOS inhibitor
-vasoconscriction
-reduction of pain

66
Q

Glyceryl trinitrate

A

NO donor
-vaso dilation in heart
——-
-angina
- heart attack

67
Q

Nirtoprusside

A

NO donor
-decreases BP
—–
-hypertension

68
Q

Statins

A

increase NO production

69
Q

Sildenafil

A

PDE5 inhibitor
-vasodilation
-decreased BP
———
-erectile dysfunction

70
Q

Tadarafil

A

PDE5 inhibitor
-vasodilation
-decreased BP
———
-erectile dysfunction

71
Q

Nicotine

A

nAChR agonist
-increase HR/BP
-CNS stimulant
-increase gland secretion

72
Q

Tubrocarine

A

nAChR antagonist
-decrease BP
-CNS depressant
-block heart reflexes
-paralytic

73
Q

Cyproheptidine

A

5-HT 2 antagonist
-vasodilation
——
-migraine

Pharm 203 (38 decks)

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