Purines Flashcards
1
Q
endogenous purine effects
A
-DNA/RNA synthesis
-Metabolism
-blood flow
-platelet aggregation
-neurotransmission
-immune response
2
Q
Purinergic receptors
A
Adenosine receptors (1-3) GCPR Gi/o
P2Y (1-14) GCPR mixed
P2X, ATP gated cation channels
3
Q
cardiovascular adenosine effects
A
-inhibits cardiac conduction
-increases coronary vasodilation
-anti coagulant
4
Q
CNS adenosine effects
A
-Inhibitory effect
-therefore caffeine (antagonist) acts as stimulant
5
Q
A1R effects
A
-activates mast cells and leukocyte activation
-enhances mucus in lungs
-bronchoconstriction
6
Q
ADP storage
A
in vesicles for exocytosis
7
Q
ATP storage
A
free in cytosol, can be exocytosed or via channels
8
Q
ATP inflammation
A
is released from apoptosis and acts as chemotractant for neutrophils increasing immune/inflammation
9
Q
A
