anti depressants facts

Question 1

unipolar depression

Answer 1

one direction of symptoms

Question 2

bipolar disorder

Answer 2

depression alternating with mania

Question 3

Monoamine theory

Answer 3

depression from lack of NT
but physical effects of drugs happen in hours vs the weeks it takes to have effect?
Ketamine acts fast?

Question 4

Neuroendocrine depression effects

Answer 4

NE and 5-HT control CRH,ACTH and cortisol they are higher in depressed patients

Question 5

depression trophic effects

Answer 5

Lower brain derived neurotrophic factor and increased excitotoxicity leads to neuronal loss in hippocampus and prefrontal cortex

Question 6

NE reuptake block

Answer 6

antidepressant but sympathetic side effects

Question 7

5-HT reuptake block

Answer 7

antidepressant and anxiety but nausea and headache/serotonin syndrome

Question 8

Da reuptake block

Answer 8

antidepressant and antiparkinsons but aggravates psychosis

Question 9

M1 ACh blockade

Answer 9

dry mouth, blurred vision, anticholinergic side effects

Question 10

H1 blockade

Answer 10

sedation and hypotension

Question 11

alpha 1 blockade

Answer 11

hypotension, reflex tachycardia

Question 12

alpha 2 blockade

Answer 12

CNS stim possible decrease in depression

Question 13

D2 blockade

Answer 13

antipsychotic effect but Parkinson’s effect

Question 14

TCA secondary amines

Answer 14

block NAT more than SERT

Question 15

TCA tertiary amines

Answer 15

Block Sert more

Question 16

SSRI

Answer 16

selective serotonin reuptake inhibitor

Question 17

TCA

Answer 17

tricyclic antidepressants

Question 18

SNRI

Answer 18

serotonin and norepinephrine uptake inhibitors

Question 19

NDRI

Answer 19

norepinephrine dopamine reuptake inhibitor

Question 20

SARI

Answer 20

serotonin-2 antagonists/serotonin reuptake inhibitor

Question 21

NaSSA

Answer 21

noradrenergic/specific serotonergic agent