Neurodegenerative diseases drugs Flashcards
Levodopa
dopamine precursor
-replaces DA in brain
—
-parkinsons
often used in combination with uptake or metabolism inhibitor
—
-Has “on-off” effect sudden bradykinesia
-nausea
-confusion
-schizophrenia like syndrome
Pramipexole
\
D2 selective agonist
—
parkinsons
–
-nausea (less since selective)
-hallucinations
-insomnia
Rotigotine
/
D1/D2 non selective agonist
—
-parkinsons
—
-nausea
-hallucinations
-insomnia
selegiline
/
MAO-B inhibitor
—
-parkinsons
—
-lacks peripheral effects due to selectivity
Rasagiline
/
MAO-B inhibitor
—
-parkinsons
—
-lacks peripheral effects due to selectivity
Safinamide
/
MAO-B inhibitor
—
-parkinsons
—
-lacks peripheral effects due to selectivity
Amantadine
/
may increase release, inhibit uptake or be an agonist
—
-parkinsons
Orphenadrine
mAch antagonist
-mainly M4 inhibition on DA neurons
-disinhibition of DA release
—
-Parkinsons
-used to treat if also on antipsychotic drugs
procyclidine
mAch antagonist
-mainly M4 inhibition on DA neurons
-disinhibition of DA release
—
-Parkinsons
-used to treat if also on antipsychotic drugs
Trihexphenidyl
mAch antagonist
-mainly M4 inhibition on DA neurons
-disinhibition of DA release
—
-Parkinsons
-used to treat if also on antipsychotic drugs
Atropine
mAch antagonist
-mainly M4 inhibition on DA neurons
-disinhibition of DA release
—
-Parkinsons
-used to treat if also on antipsychotic drugs
Tetrabenazine
Vesicular monoamine transporter inhibitor
-prevents storage and release of DA
—
-huntingtons
Baclofen
GABAb receptor agonist
-tries to make up for GABA loss
—
-huntingtons
—
donepezil
AChE inhibitor
-prevents cholinergic breakdown making up for loss
—
alzheimers
rivastigmine
AChE inhibitor
-prevents cholinergic breakdown making up for loss
—
alzheimers
