Lipid lowering facts

Question 1

primary cause of dyslipidemia

Answer 1

Genetic disorders, mutations in LDLR PCSK9

Question 2

lipoprotein trends

Answer 2

The more dense they are
1.smaller
2.higher proteins, cholesterol, phospholipids

Question 3

exogenous transport pathway

Answer 3

fats from food are taken in and synthesized by the liver

Question 4

endogenous transport pathway

Answer 4

VLDL broken down by lipases in tissues releasing triglycerides and cholesterol

Question 5

reverse transport pathway

Answer 5

Reabsobtion of cholesterol by recalling HDL-cholesterol

Question 6

Statins function

Answer 6

inhibit HMG-CoA rate limiting step for cholesterol synthesis. this lowers it which increases LDL receptor recalling LDL and HDL to liver removing them from circulation

Question 7

PCSK9 action

Answer 7

Targets the PCSK9 protein that usually causes degradation of LDL receptor. inhibition of this lets the receptor be recycled to remove more LDL from the blood stream