anginal facts Flashcards
1
Q
pain during heart attack
A
lactic acid build up from anaerobic respiration
2
Q
beta block in VSMC
A
inhibits cAMP production which removes MLCK inhibition causing contraction
3
Q
Beta block in cardia
A
Inhibits cAMP which reduces activation of PKA and opens less Ca+ channels lowering CO and contraction
4
Q
Calcium block in VSMC
A
Blocks Ca+ activation of MLCK causing relaxation
5
Q
Calcium block in cardia
A
Inhibits Ca+ influx which reduces contraction
6
Q
Arterial dilators
A
Reduce after load which enhances stroke volume and CO
7
Q
Venous dilators
A
reduce preload therefore reducing CO
8
Q
Organic nitrates action
A
redistribute coronary flow because they dilate collateral vessels and venous, can more evenly spread perfusion
