General anaesthetics Flashcards
Anesthesia def
loss of all sensation/consciousness and reflexes
Analgesia def
loss of painful modalities
local anesthetic vs analgesic
anesthetic blocks all sensation where analgesic just blocks pain modalities
Intravenous anesthetics
Used for onset as they are fast but usually slow off so not used for maintenance
inhalation anesthetics
small lipid soluble molecules. Onset is slower but elimination is very fast as they are breathed out, used for maintenance
anesthetics and lipid solubility
thought that they bind to hydrophobic pockets there fore the more lipophilic the more potent
Propofol
Injectable anesthetic
-GABAa agonist
—-
anesthetic
Fast on and offset
—
-burning at inj. site
-autonomic depression
Fospropofol
Injectable anesthetic
-GABAa agonist
—-
anesthetic
Fast on and offset
—
-burning at inj. site
-autonomic depression
Thiopental
Barbiturate Injectable anesthetic
-GABAa agonist
—-
anesthetic
Fast on slow offset
—
-small therapeutic window
-burning at injection.site
-autonomic depression
Etomidate
injectable anesthetic
- GABAa agonist
—-
anesthetic
fast onset, faily fast off
—-
-less autonomic effects
-postoperative nausea
-burning at inj, site
Ketamine (anaesthetic)
Injectable anesthetic
-GABAa agonist
—-
Dissosiative anesthetic
strong analgesia
Slow onset and off
—
-psychomimetic
-postoperative nausea
-increased ICP
Midazolam
Benzo Injectable anesthetic
-GABAa agonist
—-
anesthetic (not full)
Slow on and off
—
-minimal autonomic depression
Isoflurane
inhalant anesthetic
-Two pore domain K+ agonists
—
anesthetics
medium on/off
—-
-vasodilator
-irritation
Desflurane
inhalant anesthetic
-Two pore domain K+ agonists
—
anesthetics
fast on/off
—-
-bronchospasm/cough
-irritation
sevoflurane
inhalant anesthetic
-Two pore domain K+ agonists
—
anesthetics (very potent)
fast on/off
—-
-little irritation
