Blood medication facts Flashcards
hemostasis
arrestment of bleeding from damaged vessels
Thrombosis
pathological formation of hemostatic plug that occurs in the absence of bleeding
White clot
happens in the arteriole system as RBC are too fast
-clot made of platelets and fibrin
-treated with anti-platelets
red clots
happen in the venous system made of fibrin, erythrocytes and few platelets
-treated with anti-coagulants
Platelet signalling pathway
platelet activation
-platelets release ADP or TXA2
-they cause GP2b or 3a and fibrinogen binding
-aggregation
Reyes syndrome
happens in children after viral infection and ASA use
Thienopyridines
all pro drugs
usually used in combination with ASA after heart attack
Glycoprotein antagonists
are based on RGD sequence in GP2b/3a ligands
prevent thrombosis
circulatory predisposition for coagulation
atrial fib
-immobilization of blood
-deep vein thrombosis
hyper coagulable state
malignancy (cancer)
anti clot deficiency
pregnancy
Virchows triad
the three things that define risk for coagulation
-circulatory status
-hyper coagulable state
-endothelial injury
Ca+ and coagulation
facilities binding of clotting factors with membranes (both have negative charges) allows action and keeps effect local
INR
international normalized ratio
bleeding test
UF heparin binding
Binds to AT3 and factor 2a, binds to both sections
LMWH binding
Binds just to AT3 which then binds to Xa
has more consistent effects and better half life
used to bridge warfarin therapy
