Peptide/Proteins

Question 1

neurotransmitter proteins

Answer 1

Often co-transmitters
cause inflammation (histamine + vasodilation)
-Substance P
-NeurokininA
-CGRP calcitonin gene released protein
-Neuropeptide Y

Question 2

Bradykinin synthesis

Answer 2

from plasma protein kininogen by protease kallikrein
Broken down by ACE

Question 3

bradykinin receptors

Answer 3

B1 and B2 G protein receptors

Question 4

Bradykinin effects

Answer 4

-vasodilation via NO and PGI2
-Vascular permeability
-stimulate nerve endings
-increase fluid secretion in airways and GI
-contact GI and uterine SM

Question 5

Growth factors

Answer 5

small proteins
bind kinase linked receptors
antagonists used for cancer treatment

Question 6

Cytokines effects

Answer 6

synthesized by immune cells during inflammation
-cause further inflammation by acting on kinase receptors phosphorylating gene factors

Question 7

Interleukins

Answer 7

cytokines that signals between leukocytes (inflammatory)

Question 8

Chemokines

Answer 8

chemoattractant cytokines

Question 9

Interferons

Answer 9

interfere with viral replication

Question 10

Colony stimulating factors

Answer 10

cytokines/growth factor cross over
like EPO