Vaccines/Immunizations Flashcards
Weakened version of the virus, cause an infection without symptoms
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, RNA VACCINE
LIVE ATTENUATED VACCINE (weakened)
Pathogen was inactivated/killed by chemicals
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, RNA VACCINE
INACTIVATED VACCINE (killed)
A specific protein or carbohydrate (polysaccharide) of the pathogen
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, RNA VACCINE
SUBUNIT/CONJUGATE VACCINE
mRNA that teaches our cells how to make a protein or piece of protein (antigen)
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, RNA VACCINE
RNA VACCINE
weakened
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, RNA VACCINE
LIVE ATTENUATED VACCINE
killed
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, RNA VACCINE
INACTIVATED VACCINE
Small amount of the virus is grown in cells
Bacteria Vaccines, Virus Vaccines
Virus Vaccines
Small amounts of bacteria is grown in a growth medium
Bacteria Vaccines, Virus Vaccines
Bacteria Vaccines,
Common cell types include chicken embryos
Bacteria Vaccines, Virus Vaccines
Virus Vaccines
Separate and take as much of the pathogen as
possible from the cells/growth mediums
adjuvant, Isolate and Purify, Stabilizers, Preservatives
Isolate and Purify
? is added to help enhance an immune response
adjuvant, Isolate and Purify, Stabilizers, Preservatives
adjuvant
added for safety Primarily for multi-use vials to prevent bacteria/fungal growth in the vial
adjuvant, Isolate and Purify, Stabilizers, reconstitution, Preservatives
Preservatives
? may be added to increase shelf life
adjuvant, Isolate and Purify, Stabilizers, reconstitution, Preservatives
Stabilizers
Manufacturer provides the Vaccine + Diluent (Rehydration)
adjuvant, Isolate and Purify, Stabilizers, reconstitution, Preservatives
reconstitution
target
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Antigen
thimerosal
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Preservatives
(aluminum salts)
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Adjuvants
(gelatin, sugars)
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Stabilizers
neomycin
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Residual antibiotics
yeast, egg proteins, formaldehyde
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Manufacturing by-products
The primary ingredient- Depends on type of vaccine
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Antigen
Added to prevent contamination from other bacteria (think of a multi-use vial)
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Preservatives
Added to help boost the body’s response to the vaccine
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Adjuvants
Keep the vaccine effective after it was manufactured
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Stabilizers
To prevent contamination by bacteria during manufacturing
Preservatives, Adjuvants, Antigen, Residual antibiotics, Stabilizers, Manufacturing by-products
Residual antibiotics
We do NOT need to grow the virus/bacteria/pathogen in cells/cultures
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, MRNA VACCINE
MRNA VACCINE
Labs synthesize the mRNA and add ingredients for stability
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, MRNA VACCINE
MRNA VACCINE
FASTER manufacturing of vaccines
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, MRNA VACCINE
MRNA VACCINE
SIMPLIFIED production
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, MRNA VACCINE
MRNA VACCINE
COST EFFECTIVE manufacturing
INACTIVATED VACCINE , LIVE ATTENUATED VACCINE, SUBUNIT/CONJUGATE VACCINE, MRNA VACCINE
MRNA VACCINE
If the vial has day, month and year listed:
you can use the vial through the end of the day
T or F
T
If the vial has only month and year listed:
you can use the vial through the end of the month (including the entire last day of the month)
T or F
T
Common Example is 28 days: If the vial is punctured on 06/01/2019, the BUD ( Beyond use date) is 06/29/2019
T or F
T
PI will designate the limited time frame you can use the vaccine once it has been mixed with a diluent.
Multi-Dose Vials- or Reconstituted Vaccines
Reconstituted Vaccines-
- PI will designated a limited time frame you can use the vaccine once you punctured the vial with a needle
Multi-Dose Vials- or Reconstituted Vaccines
Multi-Dose Vials-
No LIVE vaccines for ?
a. PREGNANT PATIENTS
b. Patients on High Dose Corticosteroids (like prednisone, dexamethasone)
c. Patient with transplant receiving transplant rejection medications
d. Patients with HIV/AIDS
e. Patients with Cancer receiving Chemotherapy
f. Patient with Diabeties
a. PREGNANT PATIENTS
b. Patients on High Dose Corticosteroids (like prednisone, dexamethasone)
c. Patient with transplant receiving transplant rejection medications
d. Patients with HIV/AIDS
e. Patients with Cancer receiving Chemotherapy