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Phamacology Summer > Antineoplastic/ Chemotherapy Agents Part 1: General Class Wide Effects > Flashcards

Antineoplastic/ Chemotherapy Agents Part 1: General Class Wide Effects Flashcards

1
Q

 Rescue agent: Mesna

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

d. Cyclophosphamide

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2
Q

 Rescue Agent: Leucovorin

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

e. Methotrexate

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3
Q
  • Anti-HER2
    a. Cisplatin
    b. Vincristine
    c. Doxorubicin
    d. Cyclophosphamide
    e. Methotrexate
    f. Trastuzumab
A

f. Trastuzumab

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4
Q

Platinum Compound

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

a. Cisplatin

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5
Q

Vinca Alkaloids-

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

b. Vincristine

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6
Q

Anthracyclines

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

c. Doxorubicin

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7
Q

Nitrogen Mustard

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

d. Cyclophosphamide

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8
Q

Antimetabolites

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

e. Methotrexate

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9
Q

Monoclonal Antibody-

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

f. Trastuzumab

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10
Q

BADGOATS 1
-BONE MARROW SUPPRESSION
 ADMINISTRATION CONCERNS
which is the above

  1. Neutropenia- Infection Risk/Safety
  2. Anemia- S/S and Management
  3. Thrombocytopenia- S/S and Management
  4. Infiltration/Extravasation- S/S and Management
  5. Disposal and PPE
A
  • BONE MARROW SUPPRESSION
    1. Neutropenia- Infection Risk/Safety
    2. Anemia- S/S and Management
    3. Thrombocytopenia- S/S and Management

 ADMINISTRATION CONCERNS

  1. Infiltration/Extravasation- S/S and Management
  2. Disposal and PPE
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11
Q

BADGOATS 2
 GI TRACT CONCERNS
 OTHER PATIENT SAFETY CONCERNS
which is the above

  1. Nausea/Vomiting
  2. Oral Care, GI irritation/ulceration
  3. Alopecia
  4. Tumor Lysis Syndrome
  5. Sexual/Reproductive
A 
 GI TRACT CONCERNS
1. Nausea/Vomiting
2. Oral Care, GI irritation/ulceration
 OTHER PATIENT SAFETY CONCERNS
3. Alopecia
4. Tumor Lysis Syndrome
5. Sexual/Reproductive
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12
Q

 Neutropenia

Low point called ?

A

“Nadir”

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13
Q 
NEUTROPENIA
 PATIENT SAFETY PRECAUTIONS
which is true ?
Limit unnecessary procedures
 Live vaccines NOT recommended
 LIMIT visitors
 Do NOT allow sick/ill visitors
 risk for infection
 Do NOT allow flowers/potted plants
 Micro-organisms
 COOK and CLEAN fruits and vegetables
 No RAW fruits/veggies – risk of infection
A

all

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14
Q

“I will avoid crowds to keep from infecting others.“- WHAT IS WRONG WITH THIS
STATEMENT?

A

Large crowds can infect the immune compromised.

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15
Q

Which true about Reducing Bleeding Risk
 Bleeding Gums- soft bristle tooth brush
 Electric Razor
 Limit activities that could cause a bleed (no rugby)
 Rugby is safe

A

 Bleeding Gums- soft bristle tooth brush
 Electric Razor
 Limit activities that could cause a bleed (no rugby)

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16
Q

Thrombocytopenia
Infiltration put in order.
 3) STOP THE INFUSION AND REMOVE THE CATHETER
 1) Warm or cold compress- DEPENDS ON WHAT INFILTRATED
 4) Elevate Extremity and encourage range of motion
 2) Check with provider- how much drug did patient get? Need new
dose?

A

 3) STOP THE INFUSION AND REMOVE THE CATHETER
 4) Elevate Extremity and encourage range of motion
 1) Warm or cold compress- DEPENDS ON WHAT INFILTRATED
 2) Check with provider- how much drug did patient get? Need new
dose?

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17
Q

PREVENTION:
 Careful site selection, monitoring and securing of catheter

Extravasation or INFILTRATION

A

INFILTRATION

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18
Q

 PREVENTION:
 Use a central line
 Chemotherapy certified nurses only give chemotherapy
 Use infusion pump, monitor IV site

Extravasation or INFILTRATION

A

Extravasation

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19
Q

Thrombocytopenia
Extravasation put in order.
 1) Try to withdraw any solution from the IV access
 3) STOP THE INFUSION!
 2) Keep catheter in place- you may need to infuse an antidote
 4) Elevate Extremity and follow hospital protocol

A

 3) STOP THE INFUSION!
 1) Try to withdraw any solution from the IV access
 2) Keep catheter in place- you may need to infuse an antidote
 4) Elevate Extremity and follow hospital protocol

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20
Q

 ? Spill- Contact Occupational Safety and Health Administration (OSHA)

Large or Small Spill

A

Large

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21
Q

 ? Spill- Chemotherapy Spill Kits

Large or Small Spill

A

Small Spill

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22
Q

Goggles, mask, protective clothing, shoe covers, absorbent pads, detergent cleansers,
chemotherapy waste disposal bags

Large or Small Spill

A

Small Spill

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23
Q

Which is true about
 CHEMOTHERAPY INDUCED NAUSEA/VOMITING –

 Don’t eat if nauseated
 Limit fluids prior to chemotherapy (reduce nausea)
 Eat foods at ROOM temperature (Hot Foods Increase Nausea)
 Do NOT drink extra fluids (can cause over-distention)
 Do NOT eat extra unsaturated fats (don’t break down as well)
 Patients will typically experience weight loss

A

all

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24
Q

 Oral Hygiene is Essential

 Flossing once daily (ATI has wrong answer of 4 times daily)
 AVOID Alcohol based mouthwash ( No alcohol!)
 Run toothbrush in dishwasher weekly (not monthly- ATI distractor)
 Use soft bristle tooth brush
 Magic Mouthwash- antifungal, lidocaine, antihistamine
 BLAND DIET- No hot (temperature), Avoid spicy foods, etc.
 Report Ulcers, blood in stool, etc.

A

all

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25
Q

Treatment? ALLOPURINOL

Alopecia
Tumor Lysis Syndrome
Sexual Health-

A

Tumor Lysis Syndrome

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26
Q 
USED TO TREAT-
 Wide array of cancers
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

c. Doxorubicin

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27
Q 
ADVERSE EFFECTS:
 BAD GOATS
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

c. Doxorubicin

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28
Q

c. Doxorubicin
Alopecia
 Starts ? days when beginning treatment
 Can last ? months after end of treatment

A

Alopecia
 Starts 7-10 days when beginning treatment
 Can last 2 months after end of treatment

29
Q 
ADVERSE EFFECTS
Cardiac Toxicity
Ruby red
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

c. Doxorubicin

30
Q

c. Doxorubicin
 Harmless red discoloration of bodily fluids?
Cardiac Toxicity
Ruby red

A

Ruby Red

31
Q

c. Doxorubicin
LIFE TIME LIMIT!
Cardiac Toxicity
Ruby red

A

Cardiac Toxicity

32
Q

Monitor EKG and Echocardiogram

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

c. Doxorubicin

33
Q 
 USED TO TREAT-
 Wide array of cancers
Derived from vinca rosea plant (periwinkle plant)
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

b. Vincristine

34
Q 
 MECHANISM:
 Mitotic Inhibitor
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

b. Vincristine

35
Q 
MECHANISM:
 Believed to inhibit Topoisomerase II, which inhibits
production of DNA and RNA
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

c. Doxorubicin

36
Q 
ADVERSE EFFECTS:
 BAD GOATS
 Peripheral Neuropathy
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

b. Vincristine

37
Q 
Nearly ALL patients will have
 Decreased reflexes
 Weakness
 Sensory Loss
 Paresthesias (numbness/tingling)
 30-50% of patients have autonomic nerve damage
 Constipation
 Urinary hesitancy/retention

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

b. Vincristine

38
Q 
USED TO TREAT-
 Wide array of cancers
 Includes acute lymphomas; solid
 tumors (head, neck, ovary and breast cancers);
Hodgkin’s
 and non-Hodgkin’s lymphomas; and multiple myeloma
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

d. Cyclophosphamide

39
Q 
MECHANISM:
 Kills rapid growing cells by alkylation of DNA and RNA
synthesis
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

d. Cyclophosphamide

40
Q 
ADVERSE EFFECTS:
 BAD GOATS
 Acute Hemorrhagic Cystitis
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

d. Cyclophosphamide

41
Q 
Increase fluids to 3 Liters/Day
 Monitor for blood in urine
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

d. Cyclophosphamide

42
Q 
Watch out for electrolyte abnormalities
 hyperkalemia
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

d. Cyclophosphamide

43
Q

Commonly given with Mesna (uro-protectant)

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

d. Cyclophosphamide

44
Q 
 USED TO TREAT-
 Wide array of cancers
 Includes bladder, testicular, and ovarian cancers
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

a. Cisplatin

45
Q 
MECHANISM:
 Kills rapid growing cells by alkylation of DNA and RNA
synthesis
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

a. Cisplatin

46
Q 
ADVERSE EFFECTS:
 BAD GOATS
 Highly Emetogenic
 Renal Toxicity
 Hearing Loss
 Paresthesia's
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

a. Cisplatin

47
Q 
USED TO TREAT-
 Solid Tumors (breast/lung)
 Lymphomas/Leukemia
 Rheumatoid Arthritis
 Ectopic Pregnancy
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

e. Methotrexate

48
Q 
MECHANISM:  Rheumatoid Arthritis  (?): Mechanism
isn’t 100% understood, but it does function as
anti-inflammatory and immunomodulator
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

e. Methotrexate

LOW DOSE

49
Q

MECHANISM: CANCER (?): inhibits dihydrofolate
reductase, stops cells from utilizing folic acid for
DNA synthesis (this means fast acting cells….like
cancer!!!)
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

e. Methotrexate

(HIGH DOSE

50
Q 
MECHANISM:
 Suppresses S-phase specific cell reproduction
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

e. Methotrexate

51
Q 
The Good: Kills Cancer or stops overactive immune
system 
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

e. Methotrexate

52
Q

 The Bad (high dose therapy): BAD GOATS!

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

e. Methotrexate

53
Q 
CANCER: When destroying tumors, they release DNA byproduct.
Result=hyperuricemia
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
A

e. Methotrexate

54
Q 
Patients can have extreme turnover of DNA byproduct: Tumor Lysis Syndrome
This can cause nephrotoxicity!
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
A

e. Methotrexate

55
Q

Result=hyperuricemia

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate

A

e. Methotrexate

56
Q

 This medication is Pregnancy Category X

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate

A

e. Methotrexate

57
Q

 This medication is associated with SCAR (SJS/TEN)

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate

A

e. Methotrexate

58
Q

 This medication can cause photosensitivity

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate

A

e. Methotrexate

59
Q

 This medication can cause liver toxicity

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate

A

e. Methotrexate

60
Q

 PROTECT FROM SUNLIGHT

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate

A

e. Methotrexate

61
Q 
 NOTABLE DRUG-DRUG CONCERNS:
 INCREASED EFFECTS:
 NSAIDS (including aspirin)
 Antibiotics like penicillin and sulfamethoxazole can increase
? toxicity
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
A

e. Methotrexate

62
Q 
 Leucovorin Rescue (sort of an
antidote)
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
A

e. Methotrexate

63
Q 
 In the hospital we can check ? levels
(we then dose the leucovorin based on the levels)
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
A

e. Methotrexate

64
Q

Oral versions are given ONCE WEEKLY, if you see
ONCE DAILY, BE CAREFUL!!! You could kill someone
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate

A

e. Methotrexate

65
Q 
 USED TO TREAT-
 HER2+ Breast Cancer
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

f. Trastuzumab

66
Q

? is a monoclonal antibody which binds to the extracellular
domain of the human epidermal growth factor receptor 2 protein (HER-2); it
mediates antibody-dependent cellular cytotoxicity by inhibiting proliferation
of cells which overexpress HER-2 protein.
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

f. Trastuzumab

67
Q 
ADVERSE EFFECTS:
 TWO BOXED WARNINGS:
CARDIOMYOPATHY
 INFUSION REACTIONS AND
PULMONARY TOXICITY
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

f. Trastuzumab

68
Q 
 Stop immediately if dyspnea or significant
hypotension
a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab
A

f. Trastuzumab

69
Q

Highly Emetogenic

a. Cisplatin
b. Vincristine
c. Doxorubicin
d. Cyclophosphamide
e. Methotrexate
f. Trastuzumab

A

a. Cisplatin

Phamacology Summer (48 decks)

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