Bone Disorders: Osteoporosis Flashcards
▪Bisphosphonates
a. Alendronate- “Dronate”
b. Raloxifene
a. Alendronate- “Dronate”
▪Selective Estrogen Receptor Modulator (SERM)
a. Alendronate- “Dronate”
b. Raloxifene
b. Raloxifene
•USED TO TREAT
•Osteoporosis
a. Alendronate- “Dronate”
b. Raloxifene
a. Alendronate- “Dronate”
Adverse
• ONJ- Osteonecrosis of the Jaw
a. Alendronate- “Dronate”
b. Raloxifene
a. Alendronate- “Dronate”
Adverse
• Atypical Femur Fractures
a. Alendronate- “Dronate”
b. Raloxifene
a. Alendronate- “Dronate”
a. Alendronate- “Dronate”
• Administer first thing in the morning at least ?
minutes before food/drinks/medications (some argue ?
hours)
• Administer first thing in the morning at least 30
minutes before food/drinks/medications (some argue 2
hours)
• Take with a full glass of water
a. Alendronate- “Dronate”
b. Raloxifene
a. Alendronate- “Dronate”
• Avoid chewing tablets- intensify the GI irritation
a. Alendronate- “Dronate”
b. Raloxifene
a. Alendronate- “Dronate”
•USED TO TREAT:
•Osteoporosis in post-menopausal patients
a. Alendronate- “Dronate”
b. Raloxifene
b. Raloxifene
•USED TO TREAT:
• Risk reduction for breast cancer in post-menopausal patients
a. Alendronate- “Dronate”
b. Raloxifene
b. Raloxifene
is an estrogen agonist/antagonist
a. Alendronate- “Dronate”
b. Raloxifene
b. Raloxifene
• BOXED WARNING! INCREASED RISK FOR BLOOD CLOT- DVT/PE-
a. Alendronate- “Dronate”
b. Raloxifene
b. Raloxifene
• Patients may experience hot flashes (8-29% patients report hot flashes)
a. Alendronate- “Dronate”
b. Raloxifene
b. Raloxifene
- Increased risk for Cardiovascular Disease- major
study saw increased risk for stroke
a. Alendronate- “Dronate”
b. Raloxifene
b. Raloxifene
