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Phamacology Summer > DYSLIPIDEMIA > Flashcards

DYSLIPIDEMIA Flashcards

1
Q

• HMG CoA Reductase Inhibitors

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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2
Q

• Bile Acid Sequestrants

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

b. Cholestyramine, Colesevelam

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3
Q

Fibrates

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

c. Fenofibrate

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4
Q

• Cholesterol Absorption Inhibitor

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

d. ezetimibe

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5
Q

Herbals

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

e. Fish Oil and Garlic

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6
Q 
USED TO TREAT “STATINS”
• LDL levels (1st line therapy, most potent LDL reducers)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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7
Q 
USED TO TREAT “STATINS”
• Post MI, Post stroke (lowers CRP)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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8
Q 
• MECHANISM OF ACTION
Inhibit HMG CoA Reductase in hepatocytes
• This is a rate limiting step in production of cholesterol
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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9
Q

• SUMMARY: STOPS CHOLESTEROL PRODUCTION IN LIVER

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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10
Q

• FDA Warning: Myopathy -> Rhabdomyolysis

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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11
Q

• No Grapefruit Juice!

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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12
Q 
Hepatotoxicity
• Recommend baseline LFTS
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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13
Q

• FDA Warning: Memory loss, confusion

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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14
Q

• FDA Warning: increased blood glucose, HgbA1C

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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15
Q 
CONTRAINDICATIONS
• Avoid in pregnancy and lactation (Category X)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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16
Q 
Grapefruit Juice can severely increase the statin
concentration (risk for rhabdomyolysis)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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17
Q

EXCEPTION: PRAVASTATIN, OKAY WITH GRAPEFRUIT
JUICE

a. Atorvastatin, pravastatin

A

Pravastatin

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18
Q

• Measure Creatine Kinase (CK) levels-

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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19
Q

Nighttime administration, CHRONIC therapy

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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20
Q 
This is a powder. Off label to treat
diarrhea ( binds everything)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

Cholestyramine

21
Q 
MOA
This drug binds up bile acid
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

b. Cholestyramine, Colesevelam

22
Q 
ADVERSE EFFECTS
• Constipation
• Heartburn, nausea, belching, bloating
• Lack of  Fat-soluble vitamins (ADEK)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

b. Cholestyramine, Colesevelam

23
Q

b. Cholestyramine, Colesevelam

Lack of Fat-soluble vitamins (?)

24
Q

• Take drugs 1 hour before or 4 hours after use

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

b. Cholestyramine, Colesevelam

25
Q

• DIGOXIN- 1 hour before you take ?

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

Cholestyramine

26
Q

• Pt took ?- wait 4 hours, then take digoxin

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

Cholestyramine

27
Q

DIGOXIN has a • DRUG INTERACTIONS with?

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

Cholestyramine

28
Q

Take with fluids (8 oz of water)

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid

A

b. Cholestyramine, Colesevelam

29
Q

Deals with Vitamin B3

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid

A

f. Nicotinic Acid

30
Q 
USED TO TREAT
• CHOLESTEROL!
• Can increase HDL, lower LDL and TG
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

31
Q 
USED TO TREAT
• Can increase HDL, lower LDL and TG
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

32
Q 
• ADVERSE EFFECTS
• elevated liver enzymes (extended release products)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

33
Q 
• ADVERSE EFFECTS
pruritus
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

34
Q 
• ADVERSE EFFECTS
• FLUSHING (common) RED FACE
• NSAIDS/ASA can be taken ? minutes prior
• Gradually taper up doses
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

30

f. Nicotinic Acid

35
Q 
• ADVERSE EFFECTS
• Increase in uric acid levels (hyperuricemia)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

36
Q 
• ADVERSE EFFECTS
• Increase in blood glucose (hyperglycemia)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

37
Q 
CONTRA-INDICATIONS
• peptic ulcer disease, hepatic disease, gout
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

38
Q 
ADMINISTRATION
Can administer an NSAID/ASA 30 minutes prior
• USED TO TREAT
• elevated TGs!
• Can also help increase HDL
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

f. Nicotinic Acid

39
Q 
• USED TO TREAT
• elevated TGs!
• Can also help increase HDL
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

c. Fenofibrate

40
Q 
• ADVERSE EFFECTS
rarely Myopathy
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

c. Fenofibrate

d. ezetimibe

41
Q 
• ADVERSE EFFECTS
• Hepatotoxicity - elevated liver enzymes
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

c. Fenofibrate

d. ezetimibe

42
Q 
• ADVERSE EFFECTS
• increased risk for gallstones
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

c. Fenofibrate

43
Q 
CONTRAINDICATIONS
• liver disease, gallbladder disease
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

c. Fenofibrate

44
Q 
DRUG INTERACTIONS
• Other cholesterol Meds
• Caution in gemfibrozil with statins (generally avoided,
rhabdomyolysis risk)
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

c. Fenofibrate

45
Q

• Warfarin (can increase bleed risk)

c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid

A

c. Fenofibrate

46
Q 
USED TO TREAT
Add On Medication (adjunct) to lower LDL
levels
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

d. ezetimibe

47
Q 
Which herb Used to Treat
High Cholesterol
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid
A

e. Fish Oil and Garlic

48
Q

Bleeding Risk

c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid

A

e. Fish Oil and Garlic

49
Q

Lovaza® Melts Styrofoam Cups

c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
f. Nicotinic Acid

A

e. Fish Oil and Garlic

Phamacology Summer (48 decks)

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