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Phamacology Summer > DYSLIPIDEMIA > Flashcards

DYSLIPIDEMIA Flashcards

1
Q

• HMG CoA Reductase Inhibitors

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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2
Q

• Bile Acid Sequestrants

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

b. Cholestyramine, Colesevelam

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3
Q

Fibrates

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

c. Fenofibrate

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4
Q

• Cholesterol Absorption Inhibitor

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

d. ezetimibe

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5
Q

Herbals

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

e. Fish Oil and Garlic

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6
Q 
USED TO TREAT “STATINS”
• LDL levels (1st line therapy, most potent LDL reducers)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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7
Q 
USED TO TREAT “STATINS”
• Post MI, Post stroke (lowers CRP)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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8
Q 
• MECHANISM OF ACTION
Inhibit HMG CoA Reductase in hepatocytes
• This is a rate limiting step in production of cholesterol
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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9
Q

• SUMMARY: STOPS CHOLESTEROL PRODUCTION IN LIVER

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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10
Q

• FDA Warning: Myopathy -> Rhabdomyolysis

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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11
Q

• No Grapefruit Juice!

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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12
Q 
Hepatotoxicity
• Recommend baseline LFTS
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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13
Q

• FDA Warning: Memory loss, confusion

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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14
Q

• FDA Warning: increased blood glucose, HgbA1C

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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15
Q 
CONTRAINDICATIONS
• Avoid in pregnancy and lactation (Category X)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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16
Q 
Grapefruit Juice can severely increase the statin
concentration (risk for rhabdomyolysis)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

a. Atorvastatin, pravastatin

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17
Q

EXCEPTION: PRAVASTATIN, OKAY WITH GRAPEFRUIT
JUICE

a. Atorvastatin, pravastatin

A

Pravastatin

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18
Q

• Measure Creatine Kinase (CK) levels-

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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19
Q

Nighttime administration, CHRONIC therapy

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

a. Atorvastatin, pravastatin

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20
Q 
This is a powder. Off label to treat
diarrhea ( binds everything)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

Cholestyramine

21
Q 
MOA
This drug binds up bile acid
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

b. Cholestyramine, Colesevelam

22
Q 
ADVERSE EFFECTS
• Constipation
• Heartburn, nausea, belching, bloating
• Lack of  Fat-soluble vitamins (ADEK)
a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic
A

b. Cholestyramine, Colesevelam

23
Q

b. Cholestyramine, Colesevelam

Lack of Fat-soluble vitamins (?)

24
Q

• Take drugs 1 hour before or 4 hours after use

a. Atorvastatin, pravastatin
b. Cholestyramine, Colesevelam
c. Fenofibrate
d. ezetimibe
e. Fish Oil and Garlic

A

b. Cholestyramine, Colesevelam

25
• DIGOXIN- 1 hour before you take ? a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic
Cholestyramine
26
• Pt took ?- wait 4 hours, then take digoxin a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic
Cholestyramine
27
DIGOXIN has a • DRUG INTERACTIONS with? a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic
Cholestyramine
28
Take with fluids (8 oz of water) a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid
b. Cholestyramine, Colesevelam
29
Deals with Vitamin B3 a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid
f. Nicotinic Acid
30
``` USED TO TREAT • CHOLESTEROL! • Can increase HDL, lower LDL and TG a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
31
``` USED TO TREAT • Can increase HDL, lower LDL and TG a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
32
``` • ADVERSE EFFECTS • elevated liver enzymes (extended release products) a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
33
``` • ADVERSE EFFECTS pruritus a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
34
``` • ADVERSE EFFECTS • FLUSHING (common) RED FACE • NSAIDS/ASA can be taken ? minutes prior • Gradually taper up doses a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
30 | f. Nicotinic Acid
35
``` • ADVERSE EFFECTS • Increase in uric acid levels (hyperuricemia) a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
36
``` • ADVERSE EFFECTS • Increase in blood glucose (hyperglycemia) a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
37
``` CONTRA-INDICATIONS • peptic ulcer disease, hepatic disease, gout a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
38
``` ADMINISTRATION Can administer an NSAID/ASA 30 minutes prior • USED TO TREAT • elevated TGs! • Can also help increase HDL a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
f. Nicotinic Acid
39
``` • USED TO TREAT • elevated TGs! • Can also help increase HDL a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
c. Fenofibrate
40
``` • ADVERSE EFFECTS rarely Myopathy a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
c. Fenofibrate | d. ezetimibe
41
``` • ADVERSE EFFECTS • Hepatotoxicity - elevated liver enzymes a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
c. Fenofibrate | d. ezetimibe
42
``` • ADVERSE EFFECTS • increased risk for gallstones a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
c. Fenofibrate
43
``` CONTRAINDICATIONS • liver disease, gallbladder disease a. Atorvastatin, pravastatin b. Cholestyramine, Colesevelam c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
c. Fenofibrate
44
``` DRUG INTERACTIONS • Other cholesterol Meds • Caution in gemfibrozil with statins (generally avoided, rhabdomyolysis risk) c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
c. Fenofibrate
45
• Warfarin (can increase bleed risk) c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid
c. Fenofibrate
46
``` USED TO TREAT Add On Medication (adjunct) to lower LDL levels c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
d. ezetimibe
47
``` Which herb Used to Treat High Cholesterol c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid ```
e. Fish Oil and Garlic
48
Bleeding Risk c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid
e. Fish Oil and Garlic
49
Lovaza® Melts Styrofoam Cups c. Fenofibrate d. ezetimibe e. Fish Oil and Garlic f. Nicotinic Acid
e. Fish Oil and Garlic

Phamacology Summer (48 decks)

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