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Phamacology Summer > Migrane > Flashcards

Migrane Flashcards

1
Q

Which is a Serotonin Receptor Agonist?

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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2
Q

USED TO TREAT
 Aborting an ongoing migraine attack to relieve
headache and associated symptoms

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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3
Q

MECHANISM OF ACTION
 Binds to serotonin receptors found on intracranial
blood vessels and causes vasoconstriction

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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4
Q

ADVERSE EFFECTS
Chest pain

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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5
Q

ADVERSE EFFECTS
Coronary Artery Vasospasm/Angina
 Avoid in CAD, HTN, hx of MI, or other heart disease

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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6
Q

ADVERSE Effect
Teratogenesis
 Avoid in pregnancy

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

Ergotamine

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7
Q

Which do you use for Sumatriptain- “Triptans”

  • Lying down in a dark/quiet room can help prevent severe migraine manifestations
  • Foods that can contain tyramine should be avoided
  • Avoid triggers/stress such as Emotions, Certain Drugs, Lights/Noises
  • Food with Tyramine is safe
A
  • Lying down in a dark/quiet room can help prevent severe migraine manifestations
  • Foods that can contain tyramine should be avoided
  • Avoid triggers/stress such as Emotions, Certain Drugs, Lights/Noises
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8
Q

-Lying down in a dark/quiet room can help prevent severe migraine manifestations

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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9
Q

-Foods that can contain tyramine should be avoided

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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10
Q

-Avoid triggers/stress such as Emotions, Certain Drugs, Lights/Noises

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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11
Q

Subcutaneous doses should work fast (few minutes at most for chest pain)

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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12
Q

Oral doses- patients report pain anywhere from 30-60 minutes after ingestion

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Ergotamine

A

Sumatriptain- “Triptans”

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13
Q

Do not give with MAO

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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14
Q

Use when symptoms are early to abort the migraine
as soon as the pain begins

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

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15
Q

◦ May repeat dose in 1 to 2 hours if needed

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A

Sumatriptain- “Triptans”

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16
Q

Each different route has a “max dose in 24 hours” limit (oral, subcutaneous, intranasal, rectal)

Sumatriptain- “Triptans”
Ergotamine

A

Sumatriptain- “Triptans”

17
Q

Anti- Migraine?

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

18
Q

USED TO TREAT
 Treat an oncoming migraine or abort an active migraine

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

19
Q

MECHANISM OF ACTION
 Causes vasoconstriction of cranial blood vessels

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

20
Q

ADVERSE EFFECTS:
 Do NOT give within 24 hours of a triptan- the two
together can cause extreme vasospastic reaction

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

21
Q

Physical Dependence (can have withdrawal- HA,N/V)

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

22
Q

Toxicity: Called Ergotism

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

23
Q

This is what was believed to happen at Salem Witch Trials

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

24
Q

 GI- N/V/D- give with food

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

25
Q

 Convulsions- seizures/spasms, muscle pain

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

26
Q

 Hallucinations- CNS

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

27
Q

 Extreme vasoconstriction to extremities (dry gangrene)

Sumatriptain- “Triptans”
Ergotamine

A

Ergotamine

Phamacology Summer (48 decks)

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