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Phamacology Summer > Pharmacologic Principles Part 2-Pharmacodynamics > Flashcards

Pharmacologic Principles Part 2-Pharmacodynamics Flashcards

1
Q

LOCK AND KEY CONCEPT

PHARMACOKINETICS, PHARMACEUTICS, or PHARMACODYNAMICS

A

Pharmacodynamics

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2
Q

Beta 1 receptors=

Key or LOCK

A

LOCK

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3
Q

Epinephrine/Adrenaline=

Key or LOCK

A

Key

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4
Q

Epinephrine= ? =OPENS the lock

Beta1 agonist or antagonists

A

Beta1 agonist

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5
Q

Beta blockers=? (bock the lock)

Beta1 agonist or antagonists

A

antagonists

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6
Q

Drugs=?
Locks=?
Action= ?

targets/receptors, Keys, open/close

A

Drugs=Keys
Locks=targets/receptors
Action= open/close

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7
Q

Drugs=Keys

(Open or close) LOCKS throughout body

A

Both

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8
Q

Are a reactive site on the surface or inside of a cell?

Response , Receptors, Affinity

A

Receptors

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9
Q

Drug or chemical binds to the receptor site and interacts creating a ?

Response , Receptors, Affinity

A

Response

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10
Q

Degree to which a drug attaches to a receptor?
Higher or Lower ? Wins?

Response , Receptors, Affinity

A

2x Affinity

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11
Q

LOCK AND KEY CONCEPT=

Response , Receptors, Affinity

A

Receptors

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12
Q

Could have positive/negative benefit?

Response , Receptors, Affinity

A

Response

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13
Q

Drugs that bind to receptors, but there is a response

partial agonist, agonist, antagonist

A

agonist

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14
Q

Drugs that bind to receptors with no response

partial agonist, agonist, antagonist

A

antagonist

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15
Q

Drugs prevents agonist from binding to receptor

partial agonist, agonist, antagonist

A

antagonist

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16
Q

Drug that binds to receptor, The response is diminished compared to elicited response.

partial agonist, agonist, antagonist

A

partial agonist

17
Q

Expected Pharmacological Action

Unintended Outcome or Intended Outcome

A

Intended Outcome

18
Q 
This is when someone is harmed by a medication
Could be (appropriate or inappropriate) use of the drug

Unintended Outcome or Intended Outcome

A

Unintended Outcome

Both

19
Q

1)Medication Error (?)

Appropriate or Inappropriate

A

Inappropriate

20
Q

2) Adverse Drug Reaction (?)

Appropriate or Inappropriate

A

Appropriate

21
Q

Major drug classes that cause Adverse Drug Events are:?

a. Antibiotics
b. Anticoagulants
c. Diabetes Medications
d. Opioids
e. None
g. All

A

g. All

22
Q

Which are Adverse Drug Reactions (ADRs) or ADE?

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

f. All

23
Q

Patient receives too much Morphine and stops breathing- Respiratory Rate too low

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

c. Pharmacological/ Drug Toxicity

24
Q

Patient develops HIVES when given Penicillin

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE

25
Q

Cannot be explained by known mechanisms.

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

d. Idiosyncratic

26
Q

Multiple drugs given. Competition

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

a. Drug Interactions

27
Q

Blood pressure medication given lowers the blood pressure (higher the dose given, the lower the blood pressure)- becomes hypotensive
•Opioid/Morphine given, and patient had respiratory depression

Drug Tolerance or Drug Toxicity

A

Drug Toxicity

28
Q

Body decreases response to a drug over time

Drug Tolerance or Drug Toxicity

A

Drug Tolerance

29
Q

Drug-Drug Interactions
(1+1= 2)
Hypertension- need two blood pressure medications to lower it

Synergy or Additive Effect or Antagonistic Effect

A

Additive Effect

30
Q

Drug-Drug Interactions
(1 + 1 = 6)
Can drink a few beers fine without causing any respiratory depression

Synergy or Additive Effect or Antagonistic Effect

A

Synergy

31
Q

Drug-Drug Interactions
(1 + 1 = 6)
Add opioid + alcohol= respiratory depression

Synergy or Additive Effect or Antagonistic Effect

A

Synergy

32
Q

(competition)
Morphine vs Naloxone= both compete for opioid receptors
Morphine= AGONIST
Naloxone= ANTAGONIST

Synergy or Additive Effect or Antagonistic Effect

A

Antagonistic Effect

33
Q

BE CAREFUL- IF GIVING, MONITOR CLOSELY!

CONTRA-INDICATION or PRECAUTION/CAUTION

A

PRECAUTION/CAUTION

34
Q

HARD RULE
DO NOT GIVE UNDER ANY CIRCUMSTANCES

CONTRA-INDICATION or PRECAUTION/CAUTION

A

CONTRA-INDICATION

35
Q

Nursing Process
:Before giving morphine
Check Cautions
Check Contra-indications

EVALUATE or ASSES

A

ASSES

36
Q

Nursing Process
After giving morphine
INTENDED OUTCOME
UNINTENDED OUTCOME: Adverse Drug Reaction 1.Pharmacological/ Drug Toxicity
2.Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
3.Drug-Drug Interactions

EVALUATE or ASSES

A

EVALUATE

Phamacology Summer (48 decks)

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