Pharmacologic Principles Part 2-Pharmacodynamics Flashcards by Shaquan Moore

Q

LOCK AND KEY CONCEPT

PHARMACOKINETICS, PHARMACEUTICS, or PHARMACODYNAMICS

A

Pharmacodynamics

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Q

Beta 1 receptors=

Key or LOCK

A

LOCK

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Q

Epinephrine/Adrenaline=

Key or LOCK

A

Key

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Q

Epinephrine= ? =OPENS the lock

Beta1 agonist or antagonists

A

Beta1 agonist

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Q

Beta blockers=? (bock the lock)

Beta1 agonist or antagonists

A

antagonists

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Q

Drugs=?
Locks=?
Action= ?

targets/receptors, Keys, open/close

A

Drugs=Keys
Locks=targets/receptors
Action= open/close

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Q

Drugs=Keys

(Open or close) LOCKS throughout body

A

Both

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Q

Are a reactive site on the surface or inside of a cell?

Response , Receptors, Affinity

A

Receptors

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Q

Drug or chemical binds to the receptor site and interacts creating a ?

Response , Receptors, Affinity

A

Response

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Q

Degree to which a drug attaches to a receptor?
Higher or Lower ? Wins?

Response , Receptors, Affinity

A

2x Affinity

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Q

LOCK AND KEY CONCEPT=

Response , Receptors, Affinity

A

Receptors

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Q

Could have positive/negative benefit?

Response , Receptors, Affinity

A

Response

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Q

Drugs that bind to receptors, but there is a response

partial agonist, agonist, antagonist

A

agonist

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Q

Drugs that bind to receptors with no response

partial agonist, agonist, antagonist

A

antagonist

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Q

Drugs prevents agonist from binding to receptor

partial agonist, agonist, antagonist

A

antagonist

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Q

Drug that binds to receptor, The response is diminished compared to elicited response.

partial agonist, agonist, antagonist

A

partial agonist

Q

Expected Pharmacological Action

Unintended Outcome or Intended Outcome

A

Intended Outcome

Q

This is when someone is harmed by a medication
Could be (appropriate or inappropriate) use of the drug

Unintended Outcome or Intended Outcome

A

Unintended Outcome

Both

Q

1)Medication Error (?)

Appropriate or Inappropriate

A

Inappropriate

Q

2) Adverse Drug Reaction (?)

Appropriate or Inappropriate

A

Appropriate

Q

Major drug classes that cause Adverse Drug Events are:?

a. Antibiotics
b. Anticoagulants
c. Diabetes Medications
d. Opioids
e. None
g. All

A

g. All

Q

Which are Adverse Drug Reactions (ADRs) or ADE?

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

f. All

Q

Patient receives too much Morphine and stops breathing- Respiratory Rate too low

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

c. Pharmacological/ Drug Toxicity

Q

Patient develops HIVES when given Penicillin

a. Drug Interactions
b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE
c. Pharmacological/ Drug Toxicity
d. Idiosyncratic
e. None
f. All

A

b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE

Cannot be explained by known mechanisms. a. Drug Interactions b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE c. Pharmacological/ Drug Toxicity d. Idiosyncratic e. None f. All

d. Idiosyncratic

Multiple drugs given. Competition a. Drug Interactions b. Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE c. Pharmacological/ Drug Toxicity d. Idiosyncratic e. None f. All

a. Drug Interactions

Blood pressure medication given lowers the blood pressure (higher the dose given, the lower the blood pressure)- becomes hypotensive •Opioid/Morphine given, and patient had respiratory depression Drug Tolerance or Drug Toxicity

Drug Toxicity

Body decreases response to a drug over time Drug Tolerance or Drug Toxicity

Drug Tolerance

Drug-Drug Interactions (1+1= 2) Hypertension- need two blood pressure medications to lower it Synergy or Additive Effect or Antagonistic Effect

Additive Effect

Drug-Drug Interactions (1 + 1 = 6) Can drink a few beers fine without causing any respiratory depression Synergy or Additive Effect or Antagonistic Effect

Synergy

Drug-Drug Interactions (1 + 1 = 6) Add opioid + alcohol= respiratory depression Synergy or Additive Effect or Antagonistic Effect

Synergy

(competition) Morphine vs Naloxone= both compete for opioid receptors Morphine= AGONIST Naloxone= ANTAGONIST Synergy or Additive Effect or Antagonistic Effect

Antagonistic Effect

BE CAREFUL- IF GIVING, MONITOR CLOSELY! CONTRA-INDICATION or PRECAUTION/CAUTION

PRECAUTION/CAUTION

HARD RULE DO NOT GIVE UNDER ANY CIRCUMSTANCES CONTRA-INDICATION or PRECAUTION/CAUTION

CONTRA-INDICATION

Nursing Process :Before giving morphine Check Cautions Check Contra-indications EVALUATE or ASSES

ASSES

Nursing Process After giving morphine INTENDED OUTCOME UNINTENDED OUTCOME: Adverse Drug Reaction 1.Pharmacological/ Drug Toxicity 2.Allergic/Hypersensitivity Reaction (Type through Type 4)= IMMUNE RESPONSE 3.Drug-Drug Interactions EVALUATE or ASSES

EVALUATE