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FTBHIV Flashcards

1
Q

highly toxic!

a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

d. Amphotericin B/ Liposomal Amphotericin B

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2
Q

SHAKE AND BAKE”- INFUSION REACTION

a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

d. Amphotericin B/ Liposomal Amphotericin B

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3
Q

fever, chills, rigors, muscle pain, nausea and headache around 1 to 3 hours
after drug administration
a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

d. Amphotericin B/ Liposomal Amphotericin B

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4
Q

Hypo-kalemia, Hypo-kidney

a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

d. Amphotericin B/ Liposomal Amphotericin B

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5
Q

Bone Marrow Suppression - RBCs(rare)

a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

d. Amphotericin B/ Liposomal Amphotericin B

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6
Q

For superficial infections (creams, oral

suspension) THRUSH!!!!
a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

b. Nystatin

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7
Q

Deals with Thrush

a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

b. Nystatin

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8
Q

Found as an oral troche

a. Ketoconazole
b. Nystatin
c. Fluconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

b. Nystatin

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9
Q

CYP450 enzymes

a. Ketoconazole
b. Nystatin
c. Fluconazole/Ketoconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

c. Fluconazole/ Ketoconazole

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10
Q

Primarily GI related- N/V/D

a. Ketoconazole
b. Nystatin
c. Fluconazole/ Ketoconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

c. Fluconazole

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11
Q

Hepatotoxicity
• Sex hormone alteration (decreased libido, gynecomastia, menstrual irregularities)
• GI related (N/V/D/C)
a. Ketoconazole
b. Nystatin
c. Fluconazole/ Ketoconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

c. Ketoconazole

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12
Q 
Which should you be cautious of with
Statins
• Anticoagulants/Warfarin
• Phenytoin/Seizure medications
• Transplant medications- (cyclosporine/tacrolimus)
a. Ketoconazole
b. Nystatin
c. Fluconazole/ Ketoconazole
d. Amphotericin B/ Liposomal Amphotericin B
A

c. Fluconazole/ Ketoconazole

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13
Q 
Which should you be cautious of with
Statins
• Anticoagulants/Warfarin
• Phenytoin/Seizure medications
• Transplant medications- (cyclosporine/tacrolimus)
a. Ketoconazole
b. Nystatin
c. Fluconazole/ Ketoconazole
d. Amphotericin B/ Liposomal Amphotericin B
A

c. Fluconazole/ Ketoconazole

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14
Q 
Requires monitoring of LFTs to assess
for hepatotoxicity.
a. Ketoconazole
b. Nystatin
c. Fluconazole/ Ketoconazole
d. Amphotericin B/ Liposomal Amphotericin B
A

c. Ketoconazole

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15
Q

No prazoles with ?

a. Ketoconazole
b. Nystatin
c. Fluconazole/ Ketoconazole
d. Amphotericin B/ Liposomal Amphotericin B

A

c. Fluconazole/ Ketoconazole

AZOLES

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16
Q

Usually has a skin test(PPD) or blood test result indicating TB infection

Latent or Active TB

A

Both

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17
Q

4 drugs x 8 weeks

Latent or Active TB

A

Active TB

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18
Q

1 or 2 drugs (3 to 9 months)

Latent or Active TB

A

Latent TB

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19
Q

TB =

A

RIPE

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20
Q 
RIPE is for ?
Rifampin
Isoniazid
Pyrazinamide
Ethambutol
A

TB

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21
Q

Red/orange discoloration of bodily fluids!
• This means urine, tears, sweat and saliva
• And this can stain contact lenses!
a. Rifampin
b. Isoniazid
c. Pyrazinamide
d. Ethambutol

A

a. Rifampin

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22
Q

Which is a Liver inducer?

a. Rifampin
b. Isoniazid
c. Pyrazinamide
d. Ethambutol

A

a. Rifampin

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23
Q

Which has GI upset

a. Rifampin
b. Isoniazid
c. Pyrazinamide
d. Ethambutol

A

a. Rifampin

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24
Q

Which has hepatoxicity

a. Rifampin
b. Isoniazid
c. Pyrazinamide
d. Ethambutol

A

a. Rifampin

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25
Fatal hepatitis a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
b. Isoniazid
26
Hyperglycemia a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
b. Isoniazid
27
``` • Peripheral Neuropathy • Isoniazid depletes pyridoxine (B6) a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol ```
b. Isoniazid
28
Peripheral Neuropathy | • Isoniazid depletes pyridoxine (B?)
B6
29
``` drug inhibits CYP liver enzymes Accumulation of seizure meds • Phenytoin can cause confusion + ataxia a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol ```
b. Isoniazid
30
phenytoin and carbamazepine are?
seizure meds
31
(Gout flare ups + NON Gout joint pain! (Uric Acid) a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
c. Pyrazinamide
32
• Optic Neuritis that is irreversible a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
d. Ethambutol
33
Purines> Uric Acid> Gout /Pain in Joints a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
c. Pyrazinamide
34
Isolated Nerve Problems, CYP Inhibitor, Insulin, Nausea a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
b. Isoniazid
35
Eye/Vision Problems a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
d. Ethambutol
36
Red discoloration, Rapid Metabolizer a. Rifampin b. Isoniazid c. Pyrazinamide d. Ethambutol
a. Rifampin
37
Clostridium difficile (not commonly used anymore) a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
38
Disulfirim like reaction with EtOH a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
39
N/V/D Metallic Taste (10%) a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
40
Metallic Taste (10%) a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
41
CNS Seizures, ataxia, vertigo, Headache (18%) a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
42
Peripheral Neuropathy a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
43
Darkens the urine a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
44
Super/Supra-infection: candida albicans /yeast infection a. Hydroxychloroquine b. Metronidazole
b. Metronidazole
45
It use to be used to treat • COVID-19 a. Hydroxychloroquine b. Metronidazole
a. Hydroxychloroquine
46
QT prolongation a. Hydroxychloroquine b. Metronidazole
a. Hydroxychloroquine
47
• Retinal Damage • Can be irreversible a. Hydroxychloroquine b. Metronidazole
a. Hydroxychloroquine
48
Plaquenil®, plaque in eyes a. Hydroxychloroquine b. Metronidazole
a. Hydroxychloroquine
49
• Profound hypoglycemia a. Hydroxychloroquine b. Metronidazole
a. Hydroxychloroquine
50
Not to be used in G6PD Deficiency a. Hydroxychloroquine b. Metronidazole
a. Hydroxychloroquine
51
•Herpes Virus (DNA) a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir
b. Acyclovir, Valacyclovir
52
•Influenza Virus (RNA) a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir
a. Oseltamivir
53
•COVID-19 (SARS-CoV2) a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir
c. Remdesivir
54
``` • IV Predominantly: • Phlebitis • ROTATE IV Site a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir ```
b. Acyclovir, Valacyclovir
55
• Phlebitis a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir
b. Acyclovir, Valacyclovir
56
Nephrotoxicity a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir
b. Acyclovir, Valacyclovir
57
``` Most common- GI – N/V/D • Headache, Vertigo • I still tell patients to stay hydrated a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir ```
b. Acyclovir, Valacyclovir | Oral
58
``` Burning, itching at application site • Wear gloves • Wash affected area with soap and water a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir ```
b. Acyclovir, Valacyclovir | Topical
59
For best results, take within 12 hours of onset a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir
a. Oseltamivir
60
``` USED TO TREAT: • COVID-19 in HOSPITALIZED adults and pediatrics (this is an IV therapy) a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir ```
c. Remdesivir
61
``` has both • Hepatotoxicity (AST/ALT) • Nephrotoxicity (SCr,BUN, Crcl) a. Oseltamivir b. Acyclovir, Valacyclovir c. Remdesivir ```
c. Remdesivir-Both renal and LFT
62
``` Major Concern is BONE MARROW SUPPRESSION (pancytopenia!) a. Enfuvirtide b. Maraviroc c. Zidovudine ```
c. Zidovudine
63
• Hepatomegaly/Fatty Liver a. Enfuvirtide b. Maraviroc c. Zidovudine
c. Zidovudine
64
• Lactic Acidosis a. Enfuvirtide b. Maraviroc c. Zidovudine
c. Zidovudine
65
Prevention of perinatal HIV transmission Mother to neonate a. Enfuvirtide b. Maraviroc c. Zidovudine
c. Zidovudine

Phamacology Summer (48 decks)

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