Unit 4: Pharmacology of Addiction

Question 1

L1: _________: critical for executive function in providing control over impulses from destructive behavior.

Answer 1

Prefrontal Cortex

Question 2

L1: Abuse risk is ______ with an increase in the rapidity of onset.

Answer 2

increased

Question 3

L1: Drugs with the shortest half-lives have ______ abuse potential

Answer 3

higher

Question 4

L1: Which route of administration is most likely to produce an intense rush or flash or euphoria?

Answer 4

IV

Question 5

L1: Which route of administration is most useful in addiction treatment programs?

Answer 5

Oral

Question 6

L1: Which route of administration possesses the most precise titration?

Answer 6

Inhalation

Question 7

L1: Withdrawal effects are generally more severe for drugs with _____ half-lives.

Answer 7

short

Question 8

L2: ______ reward system: connections from the prefrontal cortex to the nucleus accumbens to mediate impulse regulation

Answer 8

Reflective

Question 9

L2: _______ reward system: functions to signal immediate prospect of pleasure or pain; provides motivational and behavioral drive to achieve that pleasure/avoid that pain

Answer 9

Reactive

Question 10

L2: _______: integrative structure projecting to the VTA/nucleus accumbens, involved in formation of stimulus-reward associations.

Answer 10

Amygdala

Question 11

L2: ______: memory circuit involved in mediating associations between biologic stimuli and environmental cues

Answer 11

Hippocampus

Question 12

L2: Drugs with significant dependence liability enhance ______ activity in the _______.

Answer 12

dopamine; nucleus accumbens

Question 13

L2: Stimulation of VTA neurons by natural reinforcers results in _____ release in the ______.

Answer 13

dopamine; nucleus accumbens

Question 14

L2: The final common pathway for reinforcement and reward is the _______ pathway from the _______ to the ________.

Answer 14

mesolimbic; ventral tegmental area; nucleus accumbens

Question 15

L2: What is the order of rapidity of onset from slowest to fastest? ______

Answer 15

Oral; Mucosal; IV; Inhalation