Unit 4: Mood Disorders, Mood Stabilizers, and ADHD Flashcards
L1: Mechanism of Action? SSRIs
5HT reuptake inhbition
L1: Mechanism of Action? SNRIs
5HT + NE reuptake inhibition
L1: Name the most common MAOI.
Phenelzine
L1: Sex Demographics: _______ attempt more suicides; more ______ complete suicides.
Women; men
L1: Which pharmacologic agent? Narrow therapeutic index antimanic agent
Lithium
L2: Females tend to have more ______ symptoms in ADHD.
inattentive
L2: Mechanism of Action? Bupropion
NE + DA reuptake inhibition
L2: Mechanism of Action? Lithium
Unclear; G-protein pathways
L2: Mechanism of Action? MAOIs
Blocks degradation of NE and 5HT
L2: Mechanism of Action? Mirtazapine
Presynaptic alpha-2 antagonist (increases NE release)
L2: Mechanism of Action? Trazodone
5HT reuptake inhibition with 5HT antagonism
L2: Mechanism of Action? Tricyclic Antidepressants
NE +/- 5HT reuptake inhibition
L2: Mechanism of Action? Valproate
VSSC inhibition
L2: Name 2 SNRIs.
Venlafaxine, Duloxetine
L2: Name the most common TCA.
Amitriptyline
L2: Name the two most common stimulants used in the treatment of ADHD.
d-amphetamine (Adderall), methylphenidate (Ritalin)
L2: Which bipolar disorder pharmacologic agent? Anti-manic agents, reasonable safety/effectiveness, risk of metabolic effects/weight gain, expensive
Atypical Antipsychotics
L2: Which bipolar disorder pharmacologic agent? Anti-manic, anti-depressant, and reasonable prevention
Lithium
L2: Which bipolar disorder pharmacologic agent? Individualized treatment based on weight
Divalproex
L2: Which bipolar disorder pharmacologic agent? Not effective as preventative agent, sedation, not effective in bipolar depression
Divalproex
L2: Which bipolar disorder pharmacologic agent? Toxic/lethal in overdose
Lithium
L2: Which bipolar disorder pharmacologic agent? Tremor, taste dysfunction, thirst, cognitive dulling
Lithium
L2: Which class of antidepressants? Associated with Tyramine reaction
MAOIs
L2: Which class of antidepressants? Can cause anxiety and aggravation of psychosis
Bupropion
L2: Which class of antidepressants? Can cause hypertension and anxiety
SNRIs
L2: Which class of antidepressants? Causes sedation and antimuscarinic effects
TCAs
L2: Which class of antidepressants? Contraindicated in patients with seizure disorders or eating disorders
Bupropion
L2: Which class of antidepressants? Drowziness, dizziness, nausea, agitation
Trazodone
L2: Which class of antidepressants? EKG abnormalities that can lead to suddent death in overdose
TCAs
L2: Which class of antidepressants? Increased diastolic blood pressure
SNRIs
L2: Which class of antidepressants? Inhibits CYP450 enzymes
SSRIs
L2: Which class of antidepressants? Liver damage, hypertensive crisis when used with certain drugs
MAOIs
L2: Which class of antidepressants? May be useful in insomnia, rapid anti-anxiety effect, low incidence of sexual side effects
Mirtazapine
L2: Which class of antidepressants? More effective in severe depression
TCAs
L2: Which class of antidepressants? No sexual side effects and weight neutral
Bupropion
L2: Which pharmacologic agent? Effective for prevention of manic and depressive episodes in bipolar disorder
Lithium
L2: Which psychiatric diagnosis? May be associated with neuroendocrine dysfunction with disinhibition of HPA axis.
Depression
L3: Mechanism of Action? Electroconvulsive Therapy (ECT)
Increases activity of rate-limiting enzymes in 5HT and NE synthesis
L3: Name 3 SSRIs.
Fluoxetine, Paroxetine, Escitalopram
L3: Name the three cardinal signs of ADHD.
Excessive inattention, hyperactivity, impulsivity
L3: SIGECAPS
Sleep, Interest, Guilt, Energy, Concentration/Cognition, Appetite, Psychomotor, Suicidal ideation
L3: Which class of antidepressants? Causes orthostatic/postural hypotension
TCAs, MAOIs
L3: Which class of antidepressants? Flu-like or neurologic withdrawal symptoms
SSRIs, SNRIs
L3: Which class of antidepressants? Hyperthermia, myoclonus, muscle rigidity, and rapid changes in mental status and vital signs when administered with other select agents
SSRIs, MAOIs
L3: Which class of antidepressants? Seizures in overdose
TCAs, Bupropion
L4: Name the 4 treatments for bipolar depression in order from best to worst.
Quetiapine, lamotrigine, olanzapine/fluoxetine, lithium