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Neuro > Unit 4: Mood Disorders, Mood Stabilizers, and ADHD > Flashcards

Unit 4: Mood Disorders, Mood Stabilizers, and ADHD Flashcards

1
Q

L1: Mechanism of Action? SSRIs

A

5HT reuptake inhbition

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2
Q

L1: Mechanism of Action? SNRIs

A

5HT + NE reuptake inhibition

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3
Q

L1: Name the most common MAOI.

A

Phenelzine

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4
Q

L1: Sex Demographics: _______ attempt more suicides; more ______ complete suicides.

A

Women; men

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5
Q

L1: Which pharmacologic agent? Narrow therapeutic index antimanic agent

A

Lithium

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6
Q

L2: Females tend to have more ______ symptoms in ADHD.

A

inattentive

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7
Q

L2: Mechanism of Action? Bupropion

A

NE + DA reuptake inhibition

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8
Q

L2: Mechanism of Action? Lithium

A

Unclear; G-protein pathways

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9
Q

L2: Mechanism of Action? MAOIs

A

Blocks degradation of NE and 5HT

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10
Q

L2: Mechanism of Action? Mirtazapine

A

Presynaptic alpha-2 antagonist (increases NE release)

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11
Q

L2: Mechanism of Action? Trazodone

A

5HT reuptake inhibition with 5HT antagonism

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12
Q

L2: Mechanism of Action? Tricyclic Antidepressants

A

NE +/- 5HT reuptake inhibition

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13
Q

L2: Mechanism of Action? Valproate

A

VSSC inhibition

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14
Q

L2: Name 2 SNRIs.

A

Venlafaxine, Duloxetine

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15
Q

L2: Name the most common TCA.

A

Amitriptyline

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16
Q

L2: Name the two most common stimulants used in the treatment of ADHD.

A

d-amphetamine (Adderall), methylphenidate (Ritalin)

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17
Q

L2: Which bipolar disorder pharmacologic agent? Anti-manic agents, reasonable safety/effectiveness, risk of metabolic effects/weight gain, expensive

A

Atypical Antipsychotics

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18
Q

L2: Which bipolar disorder pharmacologic agent? Anti-manic, anti-depressant, and reasonable prevention

A

Lithium

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19
Q

L2: Which bipolar disorder pharmacologic agent? Individualized treatment based on weight

A

Divalproex

20
Q

L2: Which bipolar disorder pharmacologic agent? Not effective as preventative agent, sedation, not effective in bipolar depression

A

Divalproex

21
Q

L2: Which bipolar disorder pharmacologic agent? Toxic/lethal in overdose

A

Lithium

22
Q

L2: Which bipolar disorder pharmacologic agent? Tremor, taste dysfunction, thirst, cognitive dulling

A

Lithium

23
Q

L2: Which class of antidepressants? Associated with Tyramine reaction

A

MAOIs

24
Q

L2: Which class of antidepressants? Can cause anxiety and aggravation of psychosis

A

Bupropion

25
Q

L2: Which class of antidepressants? Can cause hypertension and anxiety

A

SNRIs

26
Q

L2: Which class of antidepressants? Causes sedation and antimuscarinic effects

A

TCAs

27
Q

L2: Which class of antidepressants? Contraindicated in patients with seizure disorders or eating disorders

A

Bupropion

28
Q

L2: Which class of antidepressants? Drowziness, dizziness, nausea, agitation

A

Trazodone

29
Q

L2: Which class of antidepressants? EKG abnormalities that can lead to suddent death in overdose

A

TCAs

30
Q

L2: Which class of antidepressants? Increased diastolic blood pressure

A

SNRIs

31
Q

L2: Which class of antidepressants? Inhibits CYP450 enzymes

A

SSRIs

32
Q

L2: Which class of antidepressants? Liver damage, hypertensive crisis when used with certain drugs

A

MAOIs

33
Q

L2: Which class of antidepressants? May be useful in insomnia, rapid anti-anxiety effect, low incidence of sexual side effects

A

Mirtazapine

34
Q

L2: Which class of antidepressants? More effective in severe depression

A

TCAs

35
Q

L2: Which class of antidepressants? No sexual side effects and weight neutral

A

Bupropion

36
Q

L2: Which pharmacologic agent? Effective for prevention of manic and depressive episodes in bipolar disorder

A

Lithium

37
Q

L2: Which psychiatric diagnosis? May be associated with neuroendocrine dysfunction with disinhibition of HPA axis.

A

Depression

38
Q

L3: Mechanism of Action? Electroconvulsive Therapy (ECT)

A

Increases activity of rate-limiting enzymes in 5HT and NE synthesis

39
Q

L3: Name 3 SSRIs.

A

Fluoxetine, Paroxetine, Escitalopram

40
Q

L3: Name the three cardinal signs of ADHD.

A

Excessive inattention, hyperactivity, impulsivity

41
Q

L3: SIGECAPS

A

Sleep, Interest, Guilt, Energy, Concentration/Cognition, Appetite, Psychomotor, Suicidal ideation

42
Q

L3: Which class of antidepressants? Causes orthostatic/postural hypotension

A

TCAs, MAOIs

43
Q

L3: Which class of antidepressants? Flu-like or neurologic withdrawal symptoms

A

SSRIs, SNRIs

44
Q

L3: Which class of antidepressants? Hyperthermia, myoclonus, muscle rigidity, and rapid changes in mental status and vital signs when administered with other select agents

A

SSRIs, MAOIs

45
Q

L3: Which class of antidepressants? Seizures in overdose

A

TCAs, Bupropion

46
Q

L4: Name the 4 treatments for bipolar depression in order from best to worst.

A

Quetiapine, lamotrigine, olanzapine/fluoxetine, lithium

Neuro (40 decks)

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