Unit 4: Anxiety Disorders and Anxiolytic-Sedative Agents

Question 1

L1: _______: recurrent thoughts, images, or impulses that are intrusive and cause anxiety

Answer 1

Obsessions

Question 2

L1: _______: repetitive behaviors or mental acts that are performed inorder to reduce anxiety

Answer 2

Compulsions

Question 3

L1: Mechanism of Action? Benzodiazepines

Answer 3

Facilitate GABA transmission

Question 4

L1: Mechansim of Action? Barbiturates

Answer 4

Facilitate GABA transmission, Depress glutamate transmission

Question 5

L1: What is the GABA subunit specificity for “Z” drugs?

Answer 5

alpha-1 subunit only

Question 6

L1: What is the GABA subunit specificity for BZDs?

Answer 6

alpha-1 and alpha-2/alpha-5

Question 7

L1: Which disorder? Palpitations, tachycardia, shortness of breath, sweating, tembling, paresthesias, fear of dying

Answer 7

Panic Disorder

Question 8

L1: Which disorder? Excessive worry, including anxiety and tension; 5% lifetime prevalence

Answer 8

Generalized Anxiety Disorder

Question 9

L1: Which disorder? Fear to leave home to do anxiety

Answer 9

Agoraphobia

Question 10

L1: Which disorder? High comorbidity with Tourette Syndrome

Answer 10

Obsessive-Compulsive Disorder

Question 11

L1: Which disorder? Overwhelming anxiety in situations where one would have to interact with others, perform in front of others, or be the center of attention

Answer 11

Social Phobia

Question 12

L2: Mechanism of Action? Buspirone

Answer 12

5HT1A partial agonist

Question 13

L2: Name 2 barbiturate agents.

Answer 13

Phenobarbital, pentobarbital

Question 14

L2: Name a BZD with reliable intramuscular administration

Answer 14

Lorazepam

Question 15

L2: What class of sedative/anxiolytic drugs are first line in acute panic disorder?

Answer 15

BZDs

Question 16

L2: Which anxiolytic agent has no sedative, anticonvulsant, or myelorelaxant aeffects?

Answer 16

Buspirone

Question 17

L2: Which pharmacologic agent acts as an antagonist at benzodiazepine binding sites to reverse CNS effects of BZDs?

Answer 17

Flumazenil

Question 18

L2: Which pharmacology agents have a withdrawal syndrome characterized by decreaed appetite, nausea, fatigue, tachycardia, insomnia, depression, weight loss, and possbile seizures? Which class of agents is more prone to this syndrome?

Answer 18

BZDs and Barbiturates; barbiturates

Question 19

L2: Which sedative agents induce P450 metabolism?

Answer 19

Barbiturates

Question 20

L2: Why are BZDs inferior agents for chronic management of anxiety disorders?

Answer 20

Dependence

Question 21

L3: Name 3 BZDs with fast oral absorption

Answer 21

Alprazolam, Triazolam, Diazepam

Question 22

L4: Name 8 BZD agents.

Answer 22

Alprazolam, Midazolam, Triazolam, Diazepam, Flurazepam, Lorazepam, Oxazepam, Temazepam