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Neuro > Unit 4: Drugs of Abuse > Flashcards

Unit 4: Drugs of Abuse Flashcards

1
Q

L1: Mechanism of Action? CNS Depressants

A

Enhance GABA activity

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2
Q

L1: Mechanism of Action? CNS Stimulants

A

Release or reuptake inhibition of catecholamines

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3
Q

L1: Mechanism of Action? Opioids

A

Mu-opioid agonists

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4
Q

L1: Name the most commonly abused IV opioid drug.

A

Heroin

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5
Q

L1: Name the three classes of CNS depressants with abuse potential.

A

Barbiturates, Benzodiazepines, Alcohol

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6
Q

L1: Which agent may be used to relieve depression and reduce nicotine craving?

A

Bupropion

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7
Q

L1: Which class of drugs has withdrawal symptoms that have significant risk of morbidity and mortality?

A

CNS depressants

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8
Q

L1: Which class of drugs requires a taper to avoid life-threatening a withdrawal syndrome?

A

CNS Depressants

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9
Q

L2: Constellation of acute toxicity symptoms associated with _________: coma, respiratory distress, pinpoint pupils, areflexia, hypotension, tachycardia

A

Opioids

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10
Q

L2: Constellation of acute toxicity symptoms associated with _________: confusion, talkativness, emotional lability, ataxia, hyporeflexia, respiratory depression, miosis, coma

A

CNS Depressants

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11
Q

L2: Constellation of acute toxicity symptoms associated with _________: Delirium, increases RR/BP/HR/Temp/DTRs, blank stare, stupor, seizures

A

Dissociative Anesthetics

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12
Q

L2: Constellation of acute toxicity symptoms associated with _________: exaggeration of panic reaction, paranoia, confusion, palpitation, convulsions

A

hallucinogens

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13
Q

L2: Constellation of acute toxicity symptoms associated with _________: nausea/vomiting, abdominal pain, salivation, diarrhea, headache/dizziness, hypotension, convulsions, respiratory pressure

A

Nicotine

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14
Q

L2: Constellation of acute toxicity symptoms associated with _________: rapid pulse, increased BP and temp, sweating, increased motor activity, arrhythmia, MI, paranoid psychosis

A

CNS Stimulants

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15
Q

L2: Constellation of acute toxicity symptoms associated with _________: Tremors, decrease in muscle strength/coordination, increased heart rate, seizures (epileptics), ketoacidosis (diabetics), hallucinations/delusions

A

Marijuana

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16
Q

L2: Marijuana acts as an agonist at ______ receptors, which increases _____ release in the _______.

A

CB1; dopamine; nucleus accumbens

17
Q

L2: Mechanism of Action? Dissociative Anesthetics (Ketamine, Phencyclidine)

A

NMDA-receptor antagonist

18
Q

L2: Mechanism of Action? Hallucinogens

A

5HT2 agonist or increased dopamine release

19
Q

L2: Name four common CNS stimulants.

A

Cocaine, Amphetamine, Methamphetamine, Nicotine

20
Q

L2: Pharmacologic agent for treatment for opioid overdose

A

Naloxone

21
Q

L2: Pharmacologic agent for treatment of alcohol overdose

A

IV fluids, glucose, vitamins, electrolytes

22
Q

L2: Pharmacologic agent for treatment of benzodiazepine overdose

A

Flumazenil

23
Q

L2: Pharmacologic agent for treatment of CNS stimulant-induced psychosis

A

Haloperidol

24
Q

L2: Pharmacologic agent for treatment of CNS stimulant-induced seizures

A

Diazepam

25
Q

L2: Which agent is a partial agonist at nicotinic receptors, enabling block of cigarette nicotine effects?

A

Varenicline

26
Q

L2: Which agent may be used for relapse prevention of opioids via action at adrenergic receptors?

A

Clonidine

27
Q

L2: Which agent may be used for withdrawal alleviation and blocking heroine reinforcement via partial agonism at mu-opioid receptors?

A

Buprenorphine

28
Q

L2: Which agent may be used for withdrawal alleviation and relapse prevention of opioids via long-acting mu-opioid agonism?

A

Methadone

29
Q

L2: Which agent may be used to block reinforcing actions of heroin via opioid receptor antagonism but has poor treatment retention?

A

Naltrexone

30
Q

L2: Which agent may be used to relieve relapse rate in alcoholics?

A

Topiramate

31
Q

L2: Which class of drugs develops strong psychologic dependence but minimal if any physical dependence

A

CNS Stimulants

32
Q

L2: Which class of drugs rarely produces tolerance, physical dependence, or withdrawal?

A

hallucinogens

33
Q

L2: Which symptom of BZDs do not usually develop tolerance?

A

Anterograde amnesia

34
Q

L2: Which symptoms of Nicotine use show tolerance?

A

Subjective effects; nausea

35
Q

L3: Name 4 drug classes of addiction that develop physical dependence

A

Opioids, CNS depressants, nicotine, marijuana

Neuro (40 decks)

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