Tumour pathology 4 Adam Flashcards
What are signal tranduction molecules
Molecules that travel to a target in cytoplasm or nucleus
What is an example of a signal tranduction molecule
BRAF
What are the ways of inhibiting/Activating target molecules
Changing shape
Phosphorylation
What are the role of transcription factors
Bind segments of DNA called promoters
What are the roles of different parts of the cell cycle
G1- growth phase
S - synthesis of DNA
G2 - further growth phase
M - Mitosis
What are the different checkpoints in the cell cycle
G1 restriction point
G2-M checkpoints
When do cells progress through a checkpoint
When there is sufficient phosphate groups
What is the role of E2F in cell cycle
Proteins with few P groups bind to E2F
(E2F can’t function when bound)
Proteins with many P release E2F
Binds DNA regulatory sequences, cell cycle goes on
Which protein controls restriction point
Retinoblastoma gene product
Are growth factors involved past restriction point
NO
What is the function of Retinoblastoma gene product
Tumour supressor gene
What is the function of HER-2 receptor
Activates pathway for phosphorylation of retinoblastoma
Allows progression to S phase
What molecule is recruited when there is DNA damage
p53
What is the function of p53
Blocks formation of phosphorylated retinoblastoma
Blocks G1 progression
Also blocks G2-M
How is DNA repaired
Mismatch repair genes
E.g MLH1
