Intro to Blood Flashcards
What is the average circulating volume of blood in a male
5L
What are the functions of blood
- Carrying compounds
- Clotting
- Defence
- Carrying gas
- Thermoregulation
- pH maintenance
What is plasma composed of
4% of body weight
95% water
What are the 3 types of plasma
- Albumin
- Globulin
- Fibronogen + more clotting stuff
What is hypoproteinaemia
Low levels of circulating plasma protein
Causes - oedema due to loss of oncotic pressure
What are the myeloid cells, WBC and RBC
How long do erythrocytes survive in blood
120 days
What is the most abundant blood cell
RBC - 4-6x10^12/L
What is involved in erythropoiesis
Controlled by erythropoietin
Secretion: 85% kidney
15% liver
Pluripotent cells->erythroblast
What are erythroblasts
Immature RBC
Blood cells that have not entered circulation
What are the different leukocytes
- Granulocytes
- Agranulocytes
What is the most and least abundant WBC
Most - Neutrophils 68%
Least - Basophils <1%
What is the cycle of monocytes
5% circulating
After 72 hrs -> connective tissue
Become macrophages
What is leukopoiesis controlled by
Cocktail of cytokines
E.g Colony stimulating factors & Interleukins
What does leukopoiesis stimulate
Both mitosis and maturation of leukocyte
