Estimating risk of inherited disease

Question 1

What does fitness mean

Answer 1

Ability of organisms to survive to pass on genes

Question 2

What does the hardy-weinburg equilibrium state

Answer 2

Allele frequencies remain constant generation to generation
Genotype frequencies remain constant

Question 3

What is genetic drift

Answer 3

Random fluctuation of one allele transmitted to high proportion of offspring

Question 4

What is the founder effect

Answer 4

Reduction in genetic variation which results in a small subset of large pop. establishes new colony

Question 5

What is the difference between bottleneck effect and founder effect

Answer 5

Bottleneck- reduces genetic diversity
Founder effect- new colony established

Question 6

What is assortive mating?

Answer 6

Choosing of partners due to shared characteristics.

Question 7

What is the frequency of the AA genotype?

Answer 7

0.8

Question 8

What is the frequency of the aa allele?

Answer 8

0.1

Question 9

What are the assumptions of the HW principle?

Answer 9

Mutation can be ignored
Migration is negligible
Mating is random
No selective pressure
Population size is large
Allele frequencies are equal in sexes

Question 10

What is carrier frequency?

Answer 10

The frequency of individuals in a population who carry a recessive mutation.