Pathogens and Host - Virus and Pathogenesis Flashcards
What are the virus pathogenic mechanisms?
Cell destruction following virus infection
Changes to cellular gene expression
Immunopathogenic disease
What are the sites of viral entry?
Conjunctiva
Arthropod
Alimentary tract
Respiratory tract
Capillary
Urogenital tract
Skin
What is a chronic infection?
Persistant virus shedding
Define viraemia
Presence of the virus in the blood
What can worsen the destruction of respiratory epithelium by influenza A virus?
Secondary bacterial infection
What is the effect of avian flu on cytokine expression?
Causes a cytokine storm
What is an antigenic drift?
Gradual evolution of viruses to generate antigenic variants
What is antigenic shift?
Significant changes in virus antigenic structure
What can have a significant action in antigenic shift?
Non - human hosts
Name some enterovirus infections
Poliomyelitis
Aseptic meningitis
Myocarditis
Pancreatitis
Respiratory infections
What can be the result of infection of the neuronal tissues?
Paralysis
Give an example of latent virus infection
Herpes
Where does a virus lay latent?
Within a nucleus in the ganglia
Give an example that might reactivate a latent virus?
Sunlight
Give two examples of virus that can cause cancer
Papillomaviruses - cervical carcinoma
Retroviruses - lymphomas and leukaemias
