Therapeutic options; cancer Flashcards

1
Q

What can be used to prevent cancer

A

Env.
Diet
Screening
Genetic
Medication

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2
Q

What are the differerent treatments for cancer

A

Surgery
Radiotherapy
Systemic therapy
Immunotherapy

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3
Q

Diet

What is red meat consumption linked to

A

Colorectal cancer

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4
Q

Diet

What is saturated fat intake associated with

A

Breast cancer

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5
Q

screening

What is the test for cervical cancer

A

Regular smear tests

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6
Q

screening

What tests are used for Colorectal cancer

A

Faecul occult blood test
16% reduction in CRC mortality

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7
Q

What is used for breast cancer screening

A

Mammography

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8
Q

What is the test for prostate cancer

A

PSA blood test

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9
Q

What are the screening options for lung cancer

A

MRI/CT scan
breath test

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10
Q

What should you look for when checking someone’s genetics for CRC & FAP

A

autosomal dominant gene
Screen families for APC mutations
Regular colonoscopy
Panprotocolectomy

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11
Q

Genetics

What genes to look out for when looking for breast cancer

A

BRCA1 & BRCA2

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12
Q

chemo-prevention

When is chemo-prevention used in oesophageal cancer, breast, H&N/ lung cancers

A

Oesohophageal- Primary
Breast- Primary
Secondary- H&N and lung cancer

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13
Q

What are the requirements for surgery & radiotherapy

A

Anatomical coverage
Treats inoperable lesions
Can make surgery possible

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14
Q

What are the 5Rs of radiobiology

A

Radiosensitivity
Repair
Re-population
Re-oxygenation
Re-assortment

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15
Q

medical treatment

What is the percentage of cancer cured by radiotherapy

A

40%

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16
Q

medical treatment

What percentage of cancers cured by chemo

A

5%

17
Q

medical treatment

What % of cancers have palliative chemo

A

50%

18
Q

medical treatment

How are targeted agents used

A

Hormone therapy- tamoxifen % ER+ breast cancer
Targeted tumour mutations- EGFR mutations & TKI agents

19
Q

What are the different immune therapies

A

Non-specific - innate
- programmed cell pathway
Specific- monoclonal antibodies
-CAR T-cells

20
Q

What cancers are PD1 and PDL-1 antagonists used for

A

Melanomas
Lung cancer

21
Q

What cancers are monoclonal antibodies used in

A

Colorectal Cancer (CRC) & cetuximab
Breast & trastuzumab
Non-Hodgkins Lymphoma (NHL) & rituximab