T cell activation Flashcards
What is the morphology of inmature dentritic cells?
They are round, no star-shaped.
Similar to macrophages as they do phagocytosis.
What produces the differenciation to Th1?
IL-12, IFNalpha, IFNB, IFNgamma
What cytokine produces Th1?
IFNgamma
What does the union of CD40L and CD40?
Activate through the classical way macrophages.
Which cytokines are proinflamatory?
IL-1,IL-6,TNFalpha, IL-12
Produced by macrophages whrn activated through the classical way.
What type of Th is involved in allergic reactions?
Th2
Why does the lepra disseminate?
Because through Th2, the macrophage is activated the alternative way and produces anti-inflammatory molecules.
What pathogen and IL activates Th2?
The helminto and IL-4.
Which Il produces Th2?
IL-4, IL-5, IL-10 and IL-13
Which IL is responsible for the activation of eosinophils?
IL-5
Which IL is responsible for intestine contraction to get rid of the helminto?
IL-13
Which IL is responisble for the Alternative Activation of Macrophages?
IL-10
What produces the macrophage which is alternatively activated?
IL-10, TGFB (antiinflammatory) and growth factors of fibroblasts (tissue repair)
What IL induces the proliferation of Th-17?
IL1, IL6, IL23 and TGFB.
Which IL produces a neutrophillic inflammation?
IL-17
