Bone tissue Flashcards

1
Q

How can the structure of the bone be divided?

A

Cortical/compact bone (outside): only bone tissue.
Cancellous bone (inside): bone, medulla, blodd vessels, BONE MARROW.

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2
Q

What type of collagen is found in bone?

A

Type I collagen

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3
Q

Is bone tissue vascular o avascular?

A

Is highly Vascularized

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4
Q

Function of Osteonectin, Osteocalcin and Osteopontin

A

Osteonectin: anchors collagen.
Osteocalcin: calcium-binding.
Osteopontin: binding of osteoblast and osteocytes.

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5
Q

What’s periosteum?

A

Non-calcified connective tissue covering the external surface of the bone.

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6
Q

Whar attaches the periosteum to the bone surface?

A

Sharpey fibers (type I collagen)

Sharpey, la de high school musical

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7
Q

Which tissue supplies osteoprogenitor cells and osteoblasts to the bone, and for what?

A

Endosteum

Thin specialized connective tissue, that lines marrow cavities.

For bone growth and repair.

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8
Q

Which cells are the precursors of osteoblasts?

A

Osteoprogenitor cells

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9
Q

Which cells secrete the osteoid matrix?

A

Oscteoblasts

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10
Q

From where originate bone lining cells?

A

From osteoblasts that did not differenciate into osteocytes.

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11
Q

Which cells are in charge of remodeling and repair of damaged bone?

A

Osteoclasts

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12
Q

Of what type of cells is the endosteum formed?

A

One cell layer of osteoprogenitor cells (endosteal cells)

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13
Q

In what type of bone can we found osteons or Haversian systems?

A

Mature bone

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14
Q

What do osteosn have inside?

And surrounding?

A

A nerve, an artery and a vein.

Inside the Harversian canal.

Surrounding they have osteocytes found inside lacunae.

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15
Q

What are canaliculi?

A

Prolongations of osteocytes which are found between canaliculi.

Used to contact each otehr and exchange molecules for communication.

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16
Q

Differences between mature and inmature bone

A

Inmature bone: unmineralized, not concentric, +++ cells arranged randomly.
Mature bone: mineralized, concentric arrangement (osteons), less cells concentrically

17
Q

From where do osteoclasts come?

A

From hemapoietic stem cells (bone marrow).

Form myeloid lineage (monocytes)

Release of growth factors (M-CSF, RANKL) by osteoblasts which induces osteoclastogenesis.

18
Q

Function of osteoclasts

A

Bone degradation

Secrete acid, collagenases and proteases

Deminarilize bone matrix and degrade collagen type I

19
Q

What inhibits osteoclastogenesis?

A

Osteoprotegerin

Receptor of RANKL (growth factor released by osteoblasts)

20
Q

Morphology of osteoclasts

A

Giant multinucleated cell, highly polarized.

21
Q

From what zone in osteoclasts do are enzymes released?

A

From the sealing zone.

22
Q

How do osteoclasts increase the area of the membrane?

A

Through the ruffled border.

There are invaginations of the membrane,

23
Q

What recruits osteoblasts?

A

The release of growth factors found in the bone by osteoclasts.