Hemostasis and Coagulation

Question 1

What type of hemostasis consists in the formation of the platelet plug?

Answer 1

The primary homeostasis.

Question 2

Platelets are fragments of…

Answer 2

Megakaryocytes

Question 3

What is the normal platelet range?

Answer 3

150.000 - 400.000 microliters(

Question 4

What two components binds GPIb-V-IX?

Answer 4

vWF and platelets (this GP is found in the membrane of platelets).

Question 5

What two components binds GPVI?

Answer 5

Collagen and platelets (stabilizes the adhesion)

Factor found in the membrane of platelets.

Question 6

Where are Von Willebrand Factors stored?

Answer 6

In the Weibel-Palade bodies (endothelium) and alpha granules (platelets)

Produced by endothelial cells and Megakyrocytes (precursor of Platelets)

Question 7

In Thrombotic Thrombocytopenia purpura the autoantibodies attack…

Answer 7

AdamTS133

No degradation of vWF which causes and increase in adherence.

Question 8

What shape is present in activated platelets?

What causes this change of shape (activation)?

Answer 8

A spherical shape with numerous pseudopods.

The increase of Ca+ caused by the interaction of vWf and GPIb-V-IX.

Question 9

What does thrombin cause?

Answer 9

It causes an increase of intraplatelet Ca2+ and therebefore, platelet activation.

Question 10

Aspirin effects can last 7 days as it’s a…

Answer 10

irreversible COX inhibitor.

COX transforms Arachidonic acid into Prostaglandin G2 and H2.

No generation of TXA2 and no vasoconstriciton.

Question 11

What protein is binded to platelets through GPIIb/IIIa?

Answer 11

Fribrinogen

Question 12

Which procoagulant factors need vitamin K?

Answer 12

Factors FII, FIV, FIX and FX.

Question 13

What is more predominant in blood procoagulants or anticoagulants?

Answer 13

Anticoagulants.

Question 14

The extrinsic and intrinsic pathway will both converge in the formation of…

Answer 14

Prothrombin Activator Complex

Question 15

What is the other sinonym for tissue factor?

Answer 15

Tissue Thromboplastin

Question 16

By what is formed the prothrombin activator complex?

Answer 16

FX + FV + Tissue Factor+ Calcium

Question 17

What is the main function of prothrombin activator complex?

Answer 17

Convert Prothrombin into thrombin.

Thrombin will convert fibrinogen to fibrin.

Question 18

What step is common in the extrinsic and intrinsic pathways?

Answer 18

The conversion of prothrombin into thrombin.

The formation of the prothrombin activator complex.

Question 19

What factor sufferes a defficiency in Hemophilia A?

Answer 19

Favtor VIII

Justo el que protege vWF.

Vidas del gato tras el zapatazo por el campesino.

Question 20

What factor sufferes a defficiency in Hemophilia B?

Answer 20

Factor IX

El gato está sano, con sus nueve vidas.

Question 21

What ion do we need in both pathways to activate Factor X?

Answer 21

Ca2+

Question 22

APTT ( Activated Partial Thromboplastin Time) on what pathway focuses?

Answer 22

On the intrinsic pathway.

Playing Table Tennis (PTT)

Question 23

PT ( Prothrombin Time) on what pathway focuses?

Answer 23

The extrinsic pathway.

Playing Tennis.

Question 24

What causes the presence of lupus anticoagulant?

Answer 24

Will produce Clots in vivo (it’s a coagulant).

In Vitro will produce an elongated time in the Mixed Coagulation test.

Question 25

What factors does Protein C degrade?

Answer 25

Degrades factors V and VIII.

El gato con 8 vidas ocupa el último sitio del tren. Solo quedan 5 sitios

El revisor que es como un comecocos (C) le intenta comer.

Question 26

What does Heparin enhance?

Answer 26

The action of antithrombin which degrades F IX, X, XI and XII.

Question 27

What test will I make to monitor patients treated with Worfarin and Sintrom Anticoagulants?

Answer 27

PT (Prothrombin Time)

S & W cause Vit. K defficiency. F II, VII, IX and X depend on K+.

Factor VII is from the extrinsic pahtway and PT measures factors in the extrinsic pathway.