Red Blood Cells physiology Flashcards
From what cell do the cells of the blood come?
From pluripotential hemapoietic stem cells.
Found in the bone marrow.
In Erythropoiesis:
Which cell expresses a large number of EPO and transferrin receptors?
CFU-E
Colony Forming Unit - Erythrocyte
Which is the first cell of the red series?
Proerytoblast
Which is the last cell with nucleus?
Orthochromatofillic Erytoblast
Which is the first cell without nucleus?
Reticulocyte
Which is the first cell found circulating in the blood?
Reticulocyte
Leaves the bone marrow by diapadesis.
Where is Erythropoietin produced?
Produced in kidney cells
Where does EPO bind?
To CFU-E
When is the production of EPO acivated?
Hypoxia induces HIF-1 and HIF-2.
EXÁMEN
Where is iron absorbved?
In the duodenum.
In what form is iron in the blood?
Ferric Iron (Fe3+)
What transporter transfers ferrous iron from entorocytes to blood?
Fe2+
Ferroportin
Which protein converts ferrous iron to ferric iron?
Fe2+ to Fe3+
Hephaestin
Name after Hephaestion-God of metal wotk, friend of Alexander the Great
How much iron must be ingested per day and how much is lost by the shedding of iron containing cells?
1-2 mg/day
In both cases.
Where is Iron stored?
Macrophages from the spleen, bone marrow and liver.
Ferritin and Hemosiderin
Which hormone regulates iron metabolism?
Hepcidin
Hep - synthesized in the liver
Ferroportin degradation, no iron to blood.
Diagnose the disease:
The patient has an increase of indirect/unconjugated bilirubin and jaundice (yellow skin)
Pathological Hemolysis
Can be…
Function of Haptoglobin
Binds to Hb preventing it’s leaking to the kidneys.
Hb excceds capacity of Haptoglobin: Hemoglobinuria.
EXÁMEN
In Pathophysiological anemia:
How can we asses the capacity of regeneration of RBCs by the bone marrow?
Through the levels of reticulocytes.
