Leukocyte Migration and Inflammation Flashcards
1
Q
To what do Integrins bind?
And Selectins?
A
Integrins-ICAMS
Selectins-Mucins
2
Q
What type of endothelial cells are found in High-endothelial Venules?
A
Cuboidal Cells
3
Q
Where are HEV found?
A
In lymohoid organs.
4
Q
What do HEV express?
A
Ligands for L-selectin.
5
Q
Which is the first interaction?
A
Selectin and Mucins
6
Q
What produces and increase of affinity of Integrins?
A
Chemokines
7
Q
CXCR5 goes to …
CCR7 goes to …
A
CXCR5 goes to CXCL13 (B zone)
CCR7 goes to CCL21/19
(Paracortex / T zone)
CXCL13
8
Q
When lymphocytes don’t get activated they go out of the lymph node by expressing…
A
S1PR1
9
Q
Effector T and B cells downregulate… in order to get out of the lymph nodes.
A
L-selectin
10
Q
What IL do neutrophils detect?
A
IL-8
11
Q
A
