Neuronal physiology: Membrane and Action Potentials and Synapse Flashcards

1
Q

What are the two gates in Na++ voltage gated channels?

A

A fast gate and a slow gate.

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2
Q

What gates are closed during activation?

A

The fast and the slow gate are open but the slow gate will close after a while.

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3
Q

What happens when the membrane is trying to reach the resting potential?

A

Hyperpolarization, the membrane goes to negative values even below the resting potential.

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4
Q

When is the absolute refractory period?

A

From the opening of the fast gate to the closing of the slow.

The values higher than the threshold (-60mV).

Impossible to fire up a new action potential (as the Na++ channels are not closed).

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5
Q

When is harder than normal to fire a new action potential?

A

During the hyperpolarization (Na+ gates closed and K+ gates opened). Relative Refractory Period.

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6
Q

Where are sodium and potassium channels located in neurons?

A

In the trigger zone, in the axon hillock.

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7
Q

Which type of muscle presents a longer hill in the action potential because of Ca++?

A

The Smooth Muscle.

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8
Q

What type of conduction allows myelin?

A

Saltatory Conduction

Faster.

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9
Q

What property of myelin makes the lenght constant higher?

A

The increase in the membrane resistance.

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10
Q

Where is in myelinated axons the action potential generated?

No me refiero al axon hillock, que también.

A

In the Nodes of Ranvier

Parts that are unmyelinated.

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11
Q

Why is better to have an axon with a greater diameter?

A

Greater diameter means less intermembrane resistance

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12
Q

Myelination reduces or increases Capacitance?

A

Reduces Capacitance.

This ONLY affects the time constant (is lower).

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13
Q

What type of temperature increases conduction?

A

High Temperatures

Cold Temperature make the conduction slower.

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14
Q

Which type of synapses are unidirectional?

A

Chemical Synapses

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15
Q

Which type of synapses have a minimal intracellular space?

A

Electrical Synapses

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16
Q

Why there are many mitochondria at the end of the axon (the presynaptic boutoun)?

A

As in these region Ca++ has entered to allow the release of Neurotransmitters through the vesicles. Ca must be expelled through a Na/Ca pump that is energy dependent. (Ca2+-ATPase).

17
Q

What in the end plate increases the surface in contact with the neurotransmitter?

A

Junctional folds

18
Q

Why the Na++/K++ voltage gated channels are not at the end plate?

A

Safety Mechanism. There is a spontanous release of the Neurotransmitters and we don’t want to be a contraction each time this happens. Need lots of Nt to generate the sufficient voltage too open the Na/K voltage gated channels that are far away.

19
Q

What potential must be reached in the muscle so there is an action potential?

A

-60mV

20
Q

How can Ach enter into the vesicles?

A

Thanks to a proton/Ach countertranspont active (ATPase).

21
Q

What type of proteins mediate the Nt vesicle fusion with the membrane?

A

SNARE proteins

Soluble NSF attachment protein recptors

22
Q

Which what protein Ca++ makes contact?

A

Synaptotagmin

Tag, it’s tagged by calcium

23
Q

Which type of receptors act in distant places?

A

Metabotropic receptors.

24
Q

Where are Type II synapses usually located?

A

At the soma and the dentritic branches.

Usually inhibitory.

25
Q

Through what mechanism is synaptic plasticity achieved?

A

Through the retrograde propagation of the action potential.

Changes in the activity of the Calcium Channels.

26
Q

What are the usally inhibitory ions?

A

K+ and Cl+

Their resting potential values are very low.

(More negative than the resting potential)

27
Q

What problem in neuronal synapses causes epilepsia?

A

A loss of inhibition.

28
Q

What type of presynaptic inhibition uses Enkephalin (pain killer)?

A

A small sustained depolarization inhibition.

29
Q
A