B cell ontogeny

Question 1

Steps of lymphocyte maturation

Answer 1

Pro-lymph, pre, inmature, mature and effector lymphocyte

Question 2

What transcription factor induces the proliferation of precursor cells?

Answer 2

IL-7

Question 3

What causes the X-linked immunodeficeincies?

Answer 3

The mutation in IL-7

No proliferation of B-precursol cells.

Question 4

What TF do late Pro-B cells express?

Answer 4

Pax5

Question 5

What marks that the B cell is no longer a precursor?

Answer 5

CD19

Question 6

At what stage is the surrogate light chain created?

Answer 6

At the early pre-B cells.

Question 7

What encodes the IL-2 receptor?

Answer 7

CD25

Question 8

What does IL-2?

Answer 8

Stimulates survival and proliferation.

Question 9

What implies RAG inhibition?

Answer 9

Allelic exclusion

Only one heavy chain is used.

Question 10

At what stage there is practically no cell death?

Answer 10

At Pre-B cell stage

Question 11

Where is the repertorie of receptors selected?

Answer 11

At the bone marrow and the spleen.

In Inmature B-cells.

Question 12

When can RAG be reactivated?

Answer 12

For receptor (light chain) editing, changing the idiotype.

In Inmature B cells

Question 13

What is the half-life of B cells?

Answer 13

4.5 months

Question 14

What cell do we have if it has high IgD levels expressed?

Answer 14

Mature B cell

Question 15

Receptor expresed from the preB stage until late stages

Answer 15

CD20