Lymphocyte activation: signalling

Question 1

What it’s formed at the membrane after receiving the signal of the Ag by the TCR?

Answer 1

The SupraMolecular Activator Complex (SMAC)

Agregados de varios TCR en una zona concreta de la membrana.

Question 2

What is the first molecule to be activated?

Answer 2

Lck

Question 3

Which is the molecule that when phosphorylated recruits adaptors?

Answer 3

LAT

Question 4

Grb-2 to what transcription factor leads?

Guarranivel B2

Answer 4

AP-1

APesta

Question 5

To what transcription factor leads PLC?

Police

Answer 5

To NFAT

No longer FAT

Question 6

What protein induces de activation of NF-kappaB?

Answer 6

PKC that comes from DAG that comes from PLC-gamma.

Question 7

Which two immunosupressors inhibit calcium binding?

Answer 7

Cyclosporine and Tacrolimus (FK506)

Question 8

Which two imunosupressors block PI-3 kinase?

Answer 8

Sirolimus and Everolimus.

Question 9

What receptor is more specific TCR or BCR?

Answer 9

BCR

Question 10

What do B cells use instead of Lck?

Answer 10

Src tyrosine kinases

Question 11

What do B cells use instead of ZAP70?

Answer 11

Syk and SLP-65