Immune Regulation and Tolerance Flashcards
1
Q
What receptor must be present in the cell so the autoreactive T cell can be activated?
A
CD80/CD86
With CD28 in the T cell.
2
Q
To what molecule does CTLA-4 bind?
A
To CD80
3
Q
How can be patients with autoimmune sicknesses and transplants be terated?
A
With analogs of CTLA-4.
4
Q
What we must administer to avoid the hemolitic disease of the newborn?
A
IgG anti-Rh
Blocks the activity of B cells.
5
Q
What cytokine produces the differentiation into Induced Treg?
A
TGF-Beta
6
Q
What transcription factor posses both Treg cells?
A
FOXp3
7
Q
Which is the receptor for IL-2?
A
CD25
8
Q
To what receptor does CD80 can bind?
A
To CTLA-4 and CD28.
9
Q
What is anergy?
A
When the cell recognizes the Ag but doesn’t become activated because it needs two signals and not one.
