B cell Activation Flashcards
Which Ag are T cell independent and why?
Polysaccharides
As it contains may repetitions of the same epitope.
Which is the cytokine receptor for the B area?
CXCR5
Which is the cytokine receptor for the T area?
CCR7
Who expresses CD40?
B cells
Which three processes take place in the germinal centers of the lymph nodes triggered by the union between CD40 and CD40L?
Proliferation (Zona oscura) and Affinity Maturation and Isotype Swithching (Zona Clara).
Which is usually the Ag in T cell dependent Ags?
Proteic Antigens
As it has many different epitopes.
Where will the interaction between T and B cells take place?
In the extrafollicular space.
Which events will take place in the ‘Zona Clara’ of the Germinal Center?
The Isotype Switching and the Affinity Maturation.
Which protein/enzyme is responsible for the events that take place in the ‘Zona Clara’?
AID
What type of molecule dictates which Isotype will the B cell switch to?
Cytokines released by the T cell.
Which IL gives rise to IgE?
IL-4
Related to Th2 and Eosinophils.
TGFB gives rise to…
IgA
TGB released by the Th17 found in the mucosa as IgA.
What gives rise to IgG?
IFN gamma
Related to Th1 and the intracellular virus and bacteria.
True or False
An Isotype Switch will change the specificity of the Ab for the Ag.
FALSE
It will only change the function of the Ab. (The constant region).
Which cell presents the unprocessed Ag to B cells in the follicular zone?
Follicular helper dentritic cells
No son para nada como unas dentritic cells normal.
