Complement System Flashcards
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Which type of enzyme can activate complement proteins?
Serin Proteases
It cleaves the proteins.
Which part of the complement is in charge of opsonitzation?
C3b and C4b
Which part of the complement is in charge of Anaphilotoxinas
C3a & C5a
The smaller fragment is ‘a’ and the bigger is ‘b’
This happens in all the complement except one, which?
C2
What does the complement system induce?
Cell lysis, opsonitzation (C3by C4b), chemotaxis (C3a & C5a) and anaphylatoxins (C3a & C5a).
Clearance of Immune Complexes.
All this leads to the death of the pathogen.
In what all the pathways converge?
They all converge in the formation of the C3-convertase.
Which leads to the formation of the C5-convertase and the MAC.
What can trigger the classical pathway?
Ab (IgM, IgG3 and IgG1) and C reactive protein.
Which proteins are specific for the Classical Pathway?
C1q and C2.
When can C1 bind to IgM?
When IgM is bound to an Ag, the binding changes the conformation of IgM from the planar shape into the staple shape.
At what step does usually the complement cascade gets amplified?
When the C3-convertase is produced.
Many C3a will be released.
What do we need to trigger the Alternative Pathway?
Factor B, Fsactor D, propertin and C3.
In the Alternative Pathway what is cleaved spontanously?
C3
What will inactivate C3 in mammalian cells?
Sialic Acid
What is highly expressed in erythrocytes to transport immune complexes away from circulation?
CR1
Which are the two ‘formulas’ to make C3 convertase?
C and ML Pathway: C4b + C2a
Alternative Pathway: C3b + Bb
