Specific antibody types Flashcards
types of antibody
IgG IgM IgA IgE IgD
how many types of light chain
2
Kappa or lambda
how many types of heavy chain
5
name of antibody denoted by its
heavy chain
valency
The valency of antibody refers to the number of antigenic determinants that an individual antibody molecule can bind.
valency of IgG
2
valency of IgM
10- due to forming a pentameric structure
valency of IgA
2,4,6
- come singularly, in pairs, in threes
valency of IgE
2
valency of IgD
2
heavy chain of IgG
Y- gamma
heavy chain of IgM
U-Mu
heavy chain of IgA
a- alpha
heavy chain of IgE
e- epsilon
heavy chain of IgD
delta
concentration in serum of IgG
8-16mg/ml
concentration in serum of IgM
0.5-2 mg/ml
concentration in serum of IgA
1-4mg/ml
concentration in serum of IgE
10-400ng/ml
concentration in serum of IgD
0-0.4mg/ml
role of IgG
secondary response
- largest conc- principle immunoglobulin within serum during immune response
antibodies become IgG after
mutation of IgM- greater affinity to epitope)
role of IgM
primary response- low affinity until b cells go through hyper mutation to rearrange genes encoding the variable domains- switching class to an IgG
role of IgA
comes in three diff shapes -monomer -dimer -trimer Protects mucus membranes
role of IgE
single Y- protects against parasites
role of IgD
no idea what they do