Specific antibody types Flashcards

1
Q

types of antibody

A
IgG
IgM
IgA
IgE
IgD
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2
Q

how many types of light chain

A

2

Kappa or lambda

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3
Q

how many types of heavy chain

A

5

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4
Q

name of antibody denoted by its

A

heavy chain

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5
Q

valency

A

The valency of antibody refers to the number of antigenic determinants that an individual antibody molecule can bind.

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6
Q

valency of IgG

A

2

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7
Q

valency of IgM

A

10- due to forming a pentameric structure

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8
Q

valency of IgA

A

2,4,6

- come singularly, in pairs, in threes

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9
Q

valency of IgE

A

2

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10
Q

valency of IgD

A

2

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11
Q

heavy chain of IgG

A

Y- gamma

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12
Q

heavy chain of IgM

A

U-Mu

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13
Q

heavy chain of IgA

A

a- alpha

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14
Q

heavy chain of IgE

A

e- epsilon

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15
Q

heavy chain of IgD

A

delta

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16
Q

concentration in serum of IgG

A

8-16mg/ml

17
Q

concentration in serum of IgM

A

0.5-2 mg/ml

18
Q

concentration in serum of IgA

A

1-4mg/ml

19
Q

concentration in serum of IgE

A

10-400ng/ml

20
Q

concentration in serum of IgD

A

0-0.4mg/ml

21
Q

role of IgG

A

secondary response

- largest conc- principle immunoglobulin within serum during immune response

22
Q

antibodies become IgG after

A

mutation of IgM- greater affinity to epitope)

23
Q

role of IgM

A

primary response- low affinity until b cells go through hyper mutation to rearrange genes encoding the variable domains- switching class to an IgG

24
Q

role of IgA

A
comes in three diff shapes
-monomer
-dimer
-trimer
Protects mucus membranes
25
Q

role of IgE

A

single Y- protects against parasites

26
Q

role of IgD

A

no idea what they do