Dendritic cells and antigen presentation Flashcards
immature dendritic cells are
good at phagocytosis but bad at presenting antigens
MHC I in the
cytosol
MHC II in the
endosomal compartment
MHC I on
all cells
MHC II on
APC, B cells and macrophages
activation of immature dendritic cell
1) PRR e.g. TLR4 recognise LPS
2) DC matures and prepares to become an APC
3) peptide anti from invading bacteria, regionally extracellular, are endocytosided
4) combine with MHC II
5) then this complex is presented on the cell surface
6) also increase in costimualtory molceules
costimulatory moleucles
CD80/86 increase
immature DCs are located i the
tissues throughout the body, including skin, git, respiratory tract
encounter with a pathogen induces
the DC to matute
T cells express which co receptors
CD8 -MHC I
CD4- MHC II
what stimulates Th17
IL-6
what does Th17 produces
IL-17 and IL-6 –> neutrophil recruitment
MHC II –>
CD4 T cell- T helper cell
MHC I –>
CD8 T cell- cytotoxic T cell
each T cell only has one
TCR which specific to pathogen