parasites- extra Flashcards

1
Q

two types of parasite

A

helminths and protozoa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

helminths consist of

A

nematodes, trematodes, cestodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

nematodes

A

roundworms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

trematodes

A

flukes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

cestodes

A

tapeworms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what type of infection

A

intestinal or systemic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

most common intestinal nematode (flatworm)

A

Ascaris lumbricoides and hookworms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

most common tissue-dwelling nematode (flatworm)

A

wucheria bancrofti

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

most common cestodes (flukes)

A

echinococcus granulosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

most common tremadoes (round worm)

A

schistose mansoni

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

example of a parasite disease

A

schistosomiasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

vector of schistosomiasis

A

water snail

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

how many species of schistosomes

A

6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how many people affected by schistosomiasis

A

> 200 million

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

where does schistosome infection occur

A

fresh water contaminated with motile, fork tailed cercariae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

life cycle of schistosomes

A
  • eggs hatch to yield motile MIRACIDIA
  • MIRICIDIA infect snails
  • MIRICIDIA mature and multiple to release infectious CERCARIAE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Free swimming Cercariae strucuturee

A

fork tailed, with long body and head (sperm with fork tail)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

when the cercariae wants to penetrate hosts skin

A

cercariae shed their tail and use proteases and mucalr action of oral suckers to penetrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

after penetrator cercariae become

A

immature shistosomula

20
Q

schistosomula migrate via

A

the circulation to reach the liver microcirculation where they mature

21
Q

schistosoumula mature to

A

schistosomes

22
Q

do worms multiply in host

A

no
- adult
females reside intimately within a canal in
the ventral body of the male

23
Q

pairs migrate

A

against the portal venous blood flow (GI to the liver) to release eggs into the veins draining the bladder and intestines

24
Q

what do eggs elicit

A

a granulomatous inflammatory
response that is believed to assist their
transit into the intestines or bladder, and
excretion from the body in the stool or
urine respectively

25
immune response to schistosomula (pair of worms): early
TH1 cells
26
immune response to schistosome eggs
TH2 respnose
27
what is the overall immune response dos schistosomes
Type 2 granulomatous
28
which antibodies are elevated
IgE
29
which innate cells are specifically activated
eosinophilia
30
cardinal feature of shistosomiasis
tissue granulomas surrounding eggs
31
TH1 release which cytokines
IFN-Y TNF-a TnF-B IL-3
32
TH2 release which cytokines
``` IL-3 IL-4 IL-5 IL-10 TGF-B ```
33
Th1- IFN-Y and TNF-a
activate macrophages
34
Th1- TNF-B
inflammatory response
35
TH!/TH2- IL-3
hematopoiesis
36
Hematopoiesis
Hematopoiesis is the process of creating new blood cells in the body.
37
which TH2 cytokines activate B cell response
IL-4 and IL-5
38
TH2: IL-10
inhibits macrophages
39
TH2: TGF-B
inhibit monocyte activation
40
summary of a Type 2 granulomatous response
circumferential infiltrate of TH2 cells
41
what are found within Type 2 granuloma
eosinophils, macrophages,fibroblasts within a dense collagen rich matrix
42
granulomatous response can be deadly when granulomatous response occurs are eggs
in the hepatic sinusoids
43
role of the granuloma
sequesters toxic | egg antigens and kills the eggs
44
when the granuloma slowly dissipates...
collagenous scars coalesce, causing cirrhosis
45
cirrhosis causes
obstruct of blood flow and the creation of varices
46
death occurs due to
bleed varices