Cancer vaccines Flashcards
to prevent cancers from spreading
need to prevent or eliminate cancer cells
the premise of cancer vaccines
is to prime the immune system to be able to see tumour cells
which responses need to be developed for NK and/or CD8T cell responses
recognising tumour antigens
- e.g. may get good antibody response- but need cytotoxic response
what are used in cancer cells
dendritic cells
why aren’t naked DNA vaccines used in humans for cancer prevention
don’t work in humans well
process of creating a DC vaccine
Take dendritic cells from the patient and exposure dendritic cells to antigen you want to prime the response against get into cytosol and elicit CD8 T cell response
why is creating a cancer DC vaccine hugely complex
have to harvest cells from patient, purify APC cells and mae sure they are differentiated into mature dendritic cells
- takes sevrage week
how expensive
100,000 per patient- however could be promising
dendritic cell cancer vaccines are in stage
4 of 14 stage IV melanoma patients showed progression free survive
heptocellular carcinoma
Take dendritic cells from the patient and exposure dendritic cells to antigen you want to prime the response against get into cytosol and elicit CD8 T cell response
