Immunotherapy summary Flashcards
many cancer ells in the body
blend in as normal cells and are not destroyed by the immune system
human antibodies can be used to
block/mediate the section b/w immune system and cancer cell
which cytokine is particularly protective against cancer
IL-2
tumour micro environment is rich in
Tumour Infiltrating T-Lymphocytes (TILs)
those who have many TILs
are more likely to survive
3 ways therapeutic monoclonal antibodies can be used
- carry cytotoxic agents to tumour
- induce ADCC or Complement-mediated Lysis
- block activity of tumour specific protein
Rituximab used to treat
Hodgkins non-lymphoma
Herceptin used to treat
breast cancer
rituximab is what sort of antibody
chimeric
herceptin is what sort of antibody
humanised
how does rituximab treat HNL
induces complement mediated lysis and ADCC
- naked mAb
rituximab is targeted against
CD20 on B cells
HNL causes
malignant growth of B cells - tumour in lymph nodes
Herceptin works by
blocking activity of tumour specific protein
Types of immunotherapy
- immune system modulators
- immune checkpoint modulators
- immune cell therapy
- active vaccintation