More complement

Question 1

Lectins are

Answer 1

soluble proteins produced by the liver

Question 2

what do lectins do

Answer 2

recognise specific carbohydrate components present on microbial surfaces

Question 3

MBL

Answer 3

manose binding lectin

Question 4

MBL was he

Answer 4

first lectin to be discovered

Question 5

MBL binds to

Answer 5

mannose-containing carbohydrates of bacteria, fungi and virus’

Question 6

MBL circulates in plasma as complex with

Answer 6

2 proteases

Question 7

what are the proteases called

Answer 7

MASP 1 and MASP 2

Question 8

activation of lectin pathway

Answer 8

MBL complex binds to microbial surface (mannose-containing carbohydrates)- this binding triggers the lectin pathway

Question 9

after MBL complexes with mannose containing carbohydrate

Answer 9

MASPs protease activity becomes activated

Question 10

MASP 2

Answer 10

cleaves C4 to C4a and C4b

Question 11

C4b

Answer 11

binds covalently to the microbial surface

Question 12

C4a

Answer 12

is released

Question 13

C2 interacts with

Answer 13

MASP2

Question 14

MASP2 cleaves C2 into

Answer 14

C2a and C2b

Question 15

C2a binds to

Answer 15

C4b

Question 16

C2a and C4b form

Answer 16

C3 convertase