Learn for tomorrow Flashcards
-zumab
humanised
-ximab
chimeric
bactieral peptide which attracts neetrophils
Formyl-methionyl peptide fMP
B-defensin
lungs and skin
a- defensin
Paneth cells of the intestin
Th1
macrophages and phagocytosis
Th2
B cells
adjuvants
a substance formulated as part of a vaccine to enhance its ability to induce protection against infection
types of adjuvant
depot
delivery vehicle
immune sitmualtor
VAT
variable antigen type- made up of variable surface glycoproteins (VSG)
common fungal infections in AIDs patients
pneumocystis pneumoniae
granzymes target
Bid( release of cytochrome C) and procaspase-2)
somatic m,utation
when genes randomly rearrange so anitbodies get a better and better fit
what does IgA need to cross epithelial barrier
secretory component to bind to polymericIgA receptor
J chains
hold antibodies together- loop
hypervariability in frameworks
hypervariable regions which form lops that combine together to form antigen binding surface
which enzymes needed for salvage pathway
Thymidine kinase (*both have) Hypoxanthine (only b cell)
mouse antibodies are
xenogenic
CDRs found on
TCR and BCR
TCR are like antibodies due to
having a constant region (C) and then a variable region (a, b)
co receptor of CD8 T cell
CD8
co receptors of CD4 t CELL
CD4
CD80/86 on APC binds to
CD28
TILs
Tumour infiltrating T lymphocytes
CD* T cells tackle
non-small cell carcinoma
cancer cells display
calreticulin- signals for phagocytes
tumour microenvironment is rich in
immunosuppressive signals
types of immune therapy
immune checkpoint modulator
( CD28, CTLA4)
Immune system modulators
Immune cell therapy
immune system modulator for cancer
IL-2
