Learn for tomorrow Flashcards

1
Q

-zumab

A

humanised

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2
Q

-ximab

A

chimeric

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3
Q

bactieral peptide which attracts neetrophils

A

Formyl-methionyl peptide fMP

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4
Q

B-defensin

A

lungs and skin

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5
Q

a- defensin

A

Paneth cells of the intestin

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6
Q

Th1

A

macrophages and phagocytosis

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7
Q

Th2

A

B cells

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8
Q

adjuvants

A

a substance formulated as part of a vaccine to enhance its ability to induce protection against infection

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9
Q

types of adjuvant

A

depot
delivery vehicle
immune sitmualtor

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10
Q

VAT

A

variable antigen type- made up of variable surface glycoproteins (VSG)

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11
Q

common fungal infections in AIDs patients

A

pneumocystis pneumoniae

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12
Q

granzymes target

A

Bid( release of cytochrome C) and procaspase-2)

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13
Q

somatic m,utation

A

when genes randomly rearrange so anitbodies get a better and better fit

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14
Q

what does IgA need to cross epithelial barrier

A

secretory component to bind to polymericIgA receptor

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15
Q

J chains

A

hold antibodies together- loop

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16
Q

hypervariability in frameworks

A

hypervariable regions which form lops that combine together to form antigen binding surface

17
Q

which enzymes needed for salvage pathway

A
Thymidine kinase (*both have)
Hypoxanthine (only b cell)
18
Q

mouse antibodies are

A

xenogenic

19
Q

CDRs found on

A

TCR and BCR

20
Q

TCR are like antibodies due to

A

having a constant region (C) and then a variable region (a, b)

21
Q

co receptor of CD8 T cell

A

CD8

22
Q

co receptors of CD4 t CELL

A

CD4

23
Q

CD80/86 on APC binds to

A

CD28

24
Q

TILs

A

Tumour infiltrating T lymphocytes

25
Q

CD* T cells tackle

A

non-small cell carcinoma

26
Q

cancer cells display

A

calreticulin- signals for phagocytes

27
Q

tumour microenvironment is rich in

A

immunosuppressive signals

28
Q

types of immune therapy

A

immune checkpoint modulator
( CD28, CTLA4)

Immune system modulators

Immune cell therapy

29
Q

immune system modulator for cancer

A

IL-2