Antibody- guided imaging of cancer Flashcards
what sort of antibodies ar used to locate cancer cells or infections by molecular imagaing
radio-labeled
what sort of systems are used
Computed tomography (CT)
Magnetic resonance Imagining (MRI)
Positron Emission Tomography (PET)- PET?CT
which elements are used to label antibodies
111Indium, 993Tc-, 68Ga, or 88Zr labeled antibodies used
which antibodies used to look for prostate cancer
Capromab reacts with prostate membrane specific antigen (PMSA) on prostate cells
- conjugated to 111I with chelator pendetide and the radio labeled antibody used to locate cancerous prostate cells
The structure of prostate-specific membrane antigen (PSMA), its binding sites for PSMA ligands and the most frequently used antibodies
ANTIBODIES e.g. J591 which binds to the active centre PsMA -inhibitors in extracellular portion
what is thernostics
therapy and diagnostics
example of theranostics
89Zr-labeled-Rituximab-PET as biomarker to assess CD20 targeting
antibody-guided imaging of infectious disease used in
Invasive Candidiasis
human commensal yeast candida is
4th most common cause of nosocomial bloodstream infection
invasive candidiasis is a disease
encompassing candidemia (blood-born yeast infection) and deep organ infections- a major diagnostic challenge
blood culture is
the current gold standard test for invasive cadidiasis
however blood culture has
poor sensitivity and turn-around time is slow- relies on yeast being present in blood at time of sampling
there is a need for a
‘non-invasive’ diagnostic test that can identify
there is a need for a
‘non-invasive’ diagnostic test that can identify infection foci in tissues
- can the use antibody-guided imaging (immunoPET/MR or IMMUNOPET/CT)
candida specific antibody
mAb MC3
