SLE

Question 1

Definiton of SLE :

Answer 1

Chronic inflammatory multi-system disease of unknown etiology.

Question 2

Symptoms of SLE (Hint: RASH OR PAIN) :

Answer 2

Rash (malar or discoid)
Ar0thritis (nonerosive)
Serositis
Hematologic disorders (ie cytopenia)

Oral/nasopharyngeal ulcers
Renal disease

Photosensitivity
Antinuclear antibodies
Immunologic disorder (anti-dsDNA, anti-Smith, anti-phospholipid)
Neurologic disorders (seizures, psychosis)

Question 3

Diagnosis of SLE :

Answer 3

ANA ( Sensitive)
Anti-DS-DNA
Anti-Smith (most specific)
Anti-Phospholipid antibodies
Decreased serum complement (C3,C4)

Question 4

Bonus question : Which drugs can induce Lupus?

Answer 4

Hydralazine
Phenytoin
Procainamide

Question 5

Treatment of SLE

Answer 5

NSAIDs, steroids, hydroxychloroquine, immunosuppressants (MTX),
and certain drugs tailored to a specific organ system.